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Neutralizing antibodies against coronaviruses

Bjorkman, Pamela J. (2021) Neutralizing antibodies against coronaviruses. In: 262nd ACS National Meeting & Exposition, 22-26 August 2021, Atlanta, GA.

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The SARS-CoV-2 virus has caused a world-wide pandemic resulting in a massive loss of lives and detrimental effects on the economies of most countries. We are using single-particle cryo-electron microscopy (cryo-EM) to solve structures of infection- and vaccination-induced antibodies complexed with the spike trimer of SARS-CoV-2 in order to elucidate the structural correlates of antibody-based immune protection. Structural comparisons allowed us to classify antibodies against the receptor-binding domain (RBD) of spike trimer into categories. These classifications and structural analyses provide rules for assigning current and future human RBD-targeting antibodies into classes, evaluating avidity effects, and suggesting combinations for clin. use, and provide insight into immune responses against SARS-CoV-2. Our structural studies have also guided the development of a potential pan-betacoronavirus vaccine. The vaccine approach involves co-display of diverse sets of RBDs from SARS-like beta coronaviruses (sarbecoviruses) on nanoparticles (mosaic-RBD-nanoparticles) that results in increased breadth of neutralizing responses in mice compared with nanoparticles presenting only SARS-CoV-2 RBDs. This modular vaccine platform could provide protection from SARS-CoV-2 as well as potential future emergent coronaviruses that could cause pandemics.

Item Type:Conference or Workshop Item (Paper)
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URLURL TypeDescription Website ItemJournal Article
Bjorkman, Pamela J.0000-0002-2277-3990
Additional Information:© 2021 American Chemical Society.
Record Number:CaltechAUTHORS:20211214-231246715
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:112445
Deposited By: Tony Diaz
Deposited On:14 Dec 2021 23:17
Last Modified:14 Dec 2021 23:17

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