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Designing optically transparent photo-crosslinked peptoid nanosheets for imaging applications

Holman, Elizabeth A. and Li, Dong and Ashby, Paul D. and Zuckermann, Ronald N. and Sternberg, Paul (2021) Designing optically transparent photo-crosslinked peptoid nanosheets for imaging applications. In: 262nd ACS National Meeting & Exposition, 22-26 August 2021, Atlanta, GA.

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Peptoid bilayer nanosheets are a new class of biocompatible 2D nanomaterial with broad applications, including sensing, membrane mimicry and pathogen binding. They are formed from the self-assembly of sequence-defined peptoid chains and can be readily functionalized to tune their properties. In order to broaden their utility, there is a need to improve their mech. stability. Here, we create nanosheets that can function as a mech. robust, optically transparent interfacial barrier for covering microfluidic channels, microscopy grids and other sample chambers. This barrier would increase hydration control in otherwise open-channel environments, permitting water-sensitive, non-destructive IR spectroscopy to be incorporated into multimodal imaging platforms. Therefore, we explored new peptoid analogs contg. photo-crosslinkable side chains that can form intra-monolayer as well as inter-layer covalent bonds. These constructs can be co-assembled in various ratios to achieve a range of desirable mech. properties to provide a new route to ultrathin, mech. robust, 2D nanomaterials that serve as optically transparent interfacial barriers for a variety of imaging techniques.

Item Type:Conference or Workshop Item (Paper)
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URLURL TypeDescription Website
Holman, Elizabeth A.0000-0002-5158-4689
Sternberg, Paul0000-0002-7699-0173
Additional Information:© 2021 American Chemical Society.
Record Number:CaltechAUTHORS:20211217-000135083
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:112496
Deposited By: Tony Diaz
Deposited On:17 Dec 2021 17:34
Last Modified:17 Dec 2021 17:34

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