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Innovation by evolution: bringing new chemistry to life

Arnold, Frances (2021) Innovation by evolution: bringing new chemistry to life. Acta Crystallographica Section A, A77 (Supplement). Art. No. a70. ISSN 2053-2733. doi:10.1107/S0108767321099293. https://resolver.caltech.edu/CaltechAUTHORS:20220107-161550932

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Abstract

Not satisfied with biology's vast catalyst repertoire, we create new enzyme catalysts and expand the chemistry of life. We use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones, thereby circumventing our profound ignorance of how sequence encodes function. With a little insight from chemistry, we can generate enzymes for transformations that are unknown in biology. These new-to-nature enzymes increase the scope of molecules and materials we can build using synthetic biology and move us closer to a sustainable world where human-invented chemistry will be genetically encoded.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1107/S0108767321099293DOIAbstract
ORCID:
AuthorORCID
Arnold, Frances0000-0002-4027-364X
Additional Information:© 2021 International Union of Crystallography.
Issue or Number:Supplement
DOI:10.1107/S0108767321099293
Record Number:CaltechAUTHORS:20220107-161550932
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220107-161550932
Official Citation:Innovation by evolution: bringing new chemistry to life. Arnold, F. (2021). Acta Cryst. A77, a70; DOI: 10.1107/S0108767321099293
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:112773
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Jan 2022 21:12
Last Modified:09 Jan 2022 21:12

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