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Wearable Bioelectronics for Chronic Wound Management

Wang, Canran and Shirzaei Sani, Ehsan and Gao, Wei (2022) Wearable Bioelectronics for Chronic Wound Management. Advanced Functional Materials, 32 (17). Art. No. 2111022. ISSN 1616-301X. doi:10.1002/adfm.202111022.

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Chronic wounds are a major healthcare issue and can adversely affect the lives of millions of patients around the world. The current wound management strategies have limited clinical efficacy due to labor-intensive lab analysis requirements, need for clinicians’ experiences, long-term and frequent interventions, limiting therapeutic efficiency and applicability. The growing field of flexible bioelectronics enables a great potential for personalized wound care owing to its advantages such as wearability, low-cost, and rapid and simple application. Herein, recent advances in the development of wearable bioelectronics for monitoring and management of chronic wounds are comprehensively reviewed. First, the design principles and the key features of bioelectronics that can adapt to the unique wound milieu features are introduced. Next, the current state of wound biosensors and on-demand therapeutic systems are summarized and highlighted. Furthermore, the design criteria of the integrated closed loop devices are discussed. Finally, the future perspectives and challenges in wearable bioelectronics for wound care are discussed.

Item Type:Article
Related URLs:
URLURL TypeDescription
Wang, Canran0000-0003-3297-9041
Shirzaei Sani, Ehsan0000-0002-4609-1505
Gao, Wei0000-0002-8503-4562
Additional Information:© 2021 Wiley-VCH GmbH. Issue Online: 25 April 2022; Version of Record online: 26 December 2021; Manuscript revised: 02 December 2021; Manuscript received: 01 November 2021. This project was supported by the National Institutes of Health grant R01HL155815, Office of Naval Research grants N00014-21-1-2483 and N00014-21-1-2845, the Translational Research Institute for Space Health through NASA NNX16AO69A, and Rothenberg Innovation Initiative (RI2) and Rosen Center for Bioengineering at California Institute of Technology. The authors declare no conflict of interest.
Group:Rosen Bioengineering Center
Funding AgencyGrant Number
Office of Naval Research (ONR)N00014-21-1-2483
Office of Naval Research (ONR)N00014-21-1-2845
Rothenberg Innovation Initiative (RI2)UNSPECIFIED
Donna and Benjamin M. Rosen Bioengineering CenterUNSPECIFIED
Subject Keywords:bioelectronics; biosensors; drug delivery; wearable devices; wound healing
Issue or Number:17
Record Number:CaltechAUTHORS:20220113-922790233
Persistent URL:
Official Citation:Wang, C., Shirzaei, E., Gao, W., Wearable Bioelectronics for Chronic Wound Management. Adv. Funct. Mater. 2022, 32, 2111022.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:112886
Deposited By: George Porter
Deposited On:13 Jan 2022 14:40
Last Modified:26 Apr 2022 21:17

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