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Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans

Feinsinger, Ashley and Pouratian, Nader and Ebadi, Hamasa and Adolphs, Ralph and Andersen, Richard and Beauchamp, Michael S. and Chang, Edward F. and Crone, Nathan E. and Collinger, Jennifer L. and Fried, Itzhak and Mamelak, Adam and Richardson, Mark and Rutishauser, Ueli and Sheth, Sameer A. and Suthana, Nanthia and Tandon, Nitin and Yoshor, Daniel (2022) Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans. Neuron, 110 (2). pp. 188-194. ISSN 0896-6273. doi:10.1016/j.neuron.2021.11.011.

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Leveraging firsthand experience, BRAIN-funded investigators conducting intracranial human neuroscience research propose two fundamental ethical commitments: (1) maintaining the integrity of clinical care and (2) ensuring voluntariness. Principles, practices, and uncertainties related to these commitments are offered for future investigation.

Item Type:Article
Related URLs:
URLURL TypeDescription
Pouratian, Nader0000-0002-0426-3241
Adolphs, Ralph0000-0002-8053-9692
Andersen, Richard0000-0002-7947-0472
Beauchamp, Michael S.0000-0002-7599-9934
Fried, Itzhak0000-0002-5962-2678
Mamelak, Adam0000-0002-4245-6431
Richardson, Mark0000-0003-2620-7387
Rutishauser, Ueli0000-0002-9207-7069
Sheth, Sameer A.0000-0001-8770-8965
Suthana, Nanthia0000-0002-8796-3277
Additional Information:© 2021 Elsevier. Available online 19 January 2022. The authors gratefully acknowledge the support of NIH BRAIN Initiative program officers and staff who organized the Research Opportunities in Humans (ROH) Consortium, including Karen David, Jim Gnadt, and Khara Ramos. We also acknowledge the contributions of other ROH Consortium members who contributed perspectives to the manuscript. Finally, we acknowledge the patients who have participated in relevant studies that have helped form the experiences and perspectives included in the current report. All investigators were supported by BRAIN Initiative and NIH funding, including U01 NS098961 (A.F. and N.P.), R01 MH121373 (A.F. and N.P.), U01 NS118739 (U.R. and A.M.), U01 NS117765 (E.C.), U01 NS103082 (N.S.), U01 NS117838 (N.S.), R01 MH110831 (A.M.), P50 MH094258 (R. Adolphs and A.M.), U01 NS103780 (R. Adolphs), U01 NS113339 (M.S.B.), R01 NS065395 (M.S.B.), U01 NS108922 (J.C.), U01 NS123125 (J.C.), U01 NS108930 (I.F.), R01 NS084017 (I.F.), U01 NS123127 (R. Andersen), U01 NS121472 (S.S.), U01 NS108923 (S.S.), R01 NS110424 (M.R.), U01 NS117836 (M.R.), U01 NS098969 (M.R.), R01 NS115929 (N.E.C.), UH3 NS114439 (N.E.C.), U01 DC016696 (N.E.C.), U01 NS117836 (N.E.C.), and U01 NS098981 (N.T. and N.E.C.). Additional support provided by NSF 1756473 (I.F.) and California Institute for Regenerative Medicine (CLIN2-12319, A.M.). S.S. received funding from McNair Foundation. R. Adolphs received funding from Simons Foundation Collaboration on the Global Brain. N.S. received funding from the McKnight Foundation. Author contributions. A.F. and N.P. led discussions, abstracted principles, and drafted, edited, and finalized the manuscript. H.E. documented discussions and edited the manuscript. All other authors significantly contributed to content and perspectives and edited the manuscript. Declaration of interests. S.S. is a consultant for Boston Scientific, Neuropace, and ZimmerBiomet. N.P. is a consultant for Abbott Laboratories. N.T. is a surgical committee member for the Medtronic SLATE trial.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funding AgencyGrant Number
NIHU01 NS098961
NIHR01 MH121373
NIHU01 NS118739
NIHU01 NS117765
NIHU01 NS103082
NIHU01 NS117838
NIHR01 MH110831
NIHP50 MH094258
NIHU01 NS103780
NIHU01 NS113339
NIHR01 NS065395
NIHU01 NS108922
NIHU01 NS123125
NIHU01 NS108930
NIHR01 NS084017
NIHU01 NS123127
NIHU01 NS121472
NIHU01 NS108923
NIHR01 NS110424
NIHU01 NS117836
NIHU01 NS098969
NIHR01 NS115929
NIHUH3 NS114439
NIHU01 DC016696
NIHU01 NS117836
NIHU01 NS098981
California Institute for Regenerative Medicine (CIRM)CLIN2-12319
Robert and Janice McNair FoundationUNSPECIFIED
Simons FoundationUNSPECIFIED
McKnight FoundationUNSPECIFIED
Issue or Number:2
Record Number:CaltechAUTHORS:20220121-968267000
Persistent URL:
Official Citation:Ashley Feinsinger, Nader Pouratian, Hamasa Ebadi, Ralph Adolphs, Richard Andersen, Michael S. Beauchamp, Edward F. Chang, Nathan E. Crone, Jennifer L. Collinger, Itzhak Fried, Adam Mamelak, Mark Richardson, Ueli Rutishauser, Sameer A. Sheth, Nanthia Suthana, Nitin Tandon, Daniel Yoshor, Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans, Neuron, Volume 110, Issue 2, 2022, Pages 188-194, ISSN 0896-6273,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:113063
Deposited By: George Porter
Deposited On:24 Jan 2022 17:03
Last Modified:24 Jan 2022 17:03

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