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The Potential of CRISPR-Guided Therapies in the Dermatology Clinic

Bhat, Prashant and Garibyan, Lilit (2022) The Potential of CRISPR-Guided Therapies in the Dermatology Clinic. JID Innovations, 2 (2). Art. No. 100103. ISSN 2667-0267. PMCID PMC8899042. doi:10.1016/j.xjidi.2022.100103. https://resolver.caltech.edu/CaltechAUTHORS:20220125-117223920

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Abstract

Over the past decade, CRISPR has rapidly made its way from the bench to the bedside, providing a newfound therapeutic avenue to not only treat genetic diseases but also permanently cure them. Although there are several clinical trials in early stages, there are so far no CRISPR-based clinical trials for cutaneous disease. In this review, we describe multiple cutaneous diseases that represent ideal targets for CRISPR-based therapeutics owing to known single gene‒causing mutations. We also explore the potential of CRISPR nucleases to treat inflammatory disorders such as eczema and psoriasis, which are not classically categorized as genodermatoses. We describe the therapeutic solutions for these diseases that are guided by various CRISPR-associated (Cas) effector proteins, for example, using Cas9 to permanently edit the DNA of somatic cells, Cas3 to target foreign DNA to combat viral/bacterial skin infections, and Cas13 to edit mutated RNA transcripts in diseases where permanent DNA editing is untenable. Furthermore, we discuss various drug delivery modalities for CRISPR therapeutics, including transdermal patches and microneedles, which are uniquely suited for dermatological diseases. In summary, we highlight the potential of CRISPR-based therapeutics to revolutionize the treatment of cutaneous disease with a goal of being accessible to the practicing dermatologist.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.xjidi.2022.100103DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8899042PubMed CentralArticle
ORCID:
AuthorORCID
Bhat, Prashant0000-0003-3832-4871
Garibyan, Lilit0000-0002-9266-0887
Additional Information:© 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. Under a Creative Commons license - Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). Received 10 November 2021, Revised 3 January 2022, Accepted 10 January 2022, Available online 25 January 2022, Version of Record 3 March 2022. PB is supported by the University of California, Los Angeles-Caltech Medical Scientist Training Program, National Institutes of Health F30CA247447, a Chen Graduate Innovator Grant, and the Josephine de Kármán Fellowship Trust. The figures were created using BioRender. Author Contributions. Conceptualization: PB, LG; Writing - Original Draft Preparation: PB; Writing - Review and Editing: PB, LG. Conflict of Interest. LG received gift/grant support from Advancing Innovation in Dermatology and LEO Pharma for the Virtual Magic Wand program. Magic Wand is a service mark of The General Hospital Corporation, the owner of Massachusetts General Hospital. The remaining author states no conflict of interest.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funders:
Funding AgencyGrant Number
UCLA-Caltech Medical Scientist Training ProgramUNSPECIFIED
NIH Postdoctoral FellowshipF30CA247447
Tianqiao and Chrissy Chen Institute for NeuroscienceUNSPECIFIED
Josephine de Kármán Fellowship TrustUNSPECIFIED
Advancing Innovation in DermatologyUNSPECIFIED
LEO PharmaUNSPECIFIED
Issue or Number:2
PubMed Central ID:PMC8899042
DOI:10.1016/j.xjidi.2022.100103
Record Number:CaltechAUTHORS:20220125-117223920
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220125-117223920
Official Citation:Prashant Bhat, Lilit Garibyan, The Potential of CRISPR-Guided Therapies in the Dermatology Clinic, JID Innovations, Volume 2, Issue 2, 2022, 100103, ISSN 2667-0267, https://doi.org/10.1016/j.xjidi.2022.100103.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:113098
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:25 Jan 2022 10:20
Last Modified:16 Aug 2022 22:55

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