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Engineering Enzymes for New‐to‐Nature Carbene Chemistry

Athavale, Soumitra V. and Chen, Kai and Arnold, Frances H. (2021) Engineering Enzymes for New‐to‐Nature Carbene Chemistry. In: Transition Metal-Catalyzed Carbene Transformations. Wiley , Weinheim, pp. 95-138. ISBN 9783527347995. https://resolver.caltech.edu/CaltechAUTHORS:20220126-25738800

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Abstract

Transition metal catalysis has traditionally been at the forefront of carbene-mediated transformations. As a complement, a new paradigm that envisions the use of enzymes to harness carbene reactivity has arisen in the past decade. Natural proteins containing competent cofactors like heme can promote carbene transfer chemistry. Directed evolution of such proteins, along with the exploration of artificial metalloproteins, has enabled the development of efficient enzyme catalysts for cyclopropanation and X–H insertion reactions with exquisite selectivity. Enzymatic carbene chemistry is emblematic of a new age of biocatalysis, where new-to-nature reactions can revolutionize the capabilities of synthetic chemistry.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/9783527829170.ch4DOIArticle
ORCID:
AuthorORCID
Athavale, Soumitra V.0000-0001-5620-6997
Chen, Kai0000-0002-3325-3536
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 2022 Wiley-VCH GmbH. Published Online: 24 December 2021; Published Print: 14 March 2022.
Subject Keywords:enzymes; biocatalysis; directed evolution; new-to-nature enzyme reactivity; carbenes; iron-heme proteins; artificial metalloenzymes; cyclopropanation; C–H functionalization; asymmetric catalysis
DOI:10.1002/9783527829170.ch4
Record Number:CaltechAUTHORS:20220126-25738800
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220126-25738800
Official Citation:Athavale, S.V., Chen, K. and Arnold, F.H. (2022). Engineering Enzymes for New-to-Nature Carbene Chemistry. In Transition Metal-Catalyzed Carbene Transformations (eds J. Wang, C.-M. Che and M.P. Doyle). https://doi.org/10.1002/9783527829170.ch4
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:113111
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Jan 2022 17:25
Last Modified:26 Jan 2022 17:25

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