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The Influence of Valve Leaflet Stiffness Variability on Aortic Wall Shear Stress

Rosakis, Alexandros and Gharib, Morteza (2022) The Influence of Valve Leaflet Stiffness Variability on Aortic Wall Shear Stress. Annals of Biomedical Engineering, 50 (1). pp. 29-38. ISSN 0090-6964. doi:10.1007/s10439-021-02899-5. https://resolver.caltech.edu/CaltechAUTHORS:20220131-669209200

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Abstract

Aortic stenosis is a common cardiac condition that impacts the aorta’s hemodynamics downstream of the affected valve. We sought to better understand how non-uniform stiffening of a stenotic aortic valve would affect the wall shear stress (WSS) experienced by the walls of the aorta and the residence time near the valve. Several experimental configurations were created by individually stiffening leaflets of a polymer aortic valve. These configurations were mounted inside an in vitro experimental setup. Digital particle image velocimetry (DPIV) was used to measure velocity profiles inside a model aorta. The DPIV results were used to estimate the WSS and residence time. Our analysis suggests that leaflet asymmetry greatly affects the amount of WSS by vectoring the systolic jet and stiffened leaflets have an increased residence time. This study indicates that valve leaflets with different stiffness conditions can have a more significant impact on wall shear stress than stenosis caused by the uniform increase in all three leaflets (and the subsequent increased systolic velocity) alone. This finding is promising for creating customizable (patient-specific) prosthetic heart valves tailored to individual patients.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/s10439-021-02899-5DOIArticle
https://rdcu.be/cF6kbPublisherFree ReadCube access
ORCID:
AuthorORCID
Rosakis, Alexandros0000-0001-9170-1002
Gharib, Morteza0000-0003-0754-4193
Additional Information:© 2021 Biomedical Engineering Society. Received 15 March 2021; Accepted 01 December 2021; Published 07 January 2022. We would like to thank Chris Roh for his technical expertise, guidance, and his work on dragonfly larvae respiration which served as a bio-inspiration for this work. We would also like to thank Foldax for providing the polymer valves used in this study. Finally, we would like to thank the Charyk Biomechanics Laboratory for providing the workspace that this work was carried out in. This Study was supported by a departmental fellowship from the Andrew and Peggy Cherng Department of Medical Engineering at the California Institute of Technology. Conflict of interest: Morteza Gharib is currently on the board of directors and a shareholder in Foldax, a polymer aortic valve company. Alexandros Rosakis declares that he has no conflict of interest.
Group:GALCIT
Funders:
Funding AgencyGrant Number
Andrew and Peggy Cherng Department of Medical EngineeringUNSPECIFIED
Subject Keywords:Aorta; Heart; Shear stress; Thrombosis; Cardiovascular system; Prosthetic devices/methods; Fluid dynamics
Issue or Number:1
DOI:10.1007/s10439-021-02899-5
Record Number:CaltechAUTHORS:20220131-669209200
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220131-669209200
Official Citation:Rosakis, A., Gharib, M. The Influence of Valve Leaflet Stiffness Variability on Aortic Wall Shear Stress. Ann Biomed Eng 50, 29–38 (2022). https://doi.org/10.1007/s10439-021-02899-5
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:113178
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Feb 2022 18:43
Last Modified:01 Feb 2022 18:43

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