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Innovative vaccine approaches—a Keystone Symposia report

Cable, Jennifer and Rappuoli, Rino and Klemm, Elizabeth J. and Kang, Gagandeep and Mutreja, Ankur and Wright, Gavin J. and Pizza, Mariagrazia and Ajay Castro, Sowmya and Hoffmann, Joseph P. and Alter, Galit and Carfi, Andrea and Pollard, Andrew J. and Krammer, Florian and Gupta, Ravindra K. and Wagner, Caroline E. and Machado, Viviane and Modjarrad, Kayvon and Corey, Lawrence and Gilbert, Peter B. and Dougan, Gordon and Lurie, Nicole and Bjorkman, Pamela J. and Chiu, Christopher and Nemes, Elisa and Gordon, Stephen B. and Steer, Andrew C. and Rudel, Thomas and Blish, Catherine A. and Sandberg, John Tyler and Brennan, Kiva and Klugman, Keith P. and Stuart, Lynda M. and Madhi, Shabir A. and Karp, Christopher L. (2022) Innovative vaccine approaches—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1511 (1). pp. 59-86. ISSN 0077-8923. doi:10.1111/nyas.14739.

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The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28–30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium “Innovative Vaccine Approaches” to discuss advances in vaccine research and development.

Item Type:Article
Related URLs:
URLURL TypeDescription
Rappuoli, Rino0000-0002-8827-254X
Klemm, Elizabeth J.0000-0002-2175-3752
Kang, Gagandeep0000-0002-3656-564X
Mutreja, Ankur0000-0002-1118-8075
Wright, Gavin J.0000-0003-0537-0863
Pizza, Mariagrazia0000-0002-7800-1404
Ajay Castro, Sowmya0000-0001-9831-2907
Hoffmann, Joseph P.0000-0001-8300-7782
Alter, Galit0000-0003-1570-9445
Carfi, Andrea0000-0001-5508-3809
Krammer, Florian0000-0003-4121-776X
Gupta, Ravindra K.0000-0001-9751-1808
Wagner, Caroline E.0000-0001-5193-2797
Modjarrad, Kayvon0000-0002-6514-5572
Corey, Lawrence0000-0002-2179-2436
Gilbert, Peter B.0000-0002-2662-9427
Lurie, Nicole0000-0003-0022-965X
Bjorkman, Pamela J.0000-0002-2277-3990
Nemes, Elisa0000-0003-1662-4961
Gordon, Stephen B.0000-0001-6576-1116
Steer, Andrew C.0000-0001-7346-0196
Rudel, Thomas0000-0003-4740-6991
Blish, Catherine A.0000-0001-6946-7627
Sandberg, John Tyler0000-0001-6747-6933
Brennan, Kiva0000-0003-4960-7076
Klugman, Keith P.0000-0001-6637-728X
Stuart, Lynda M.0000-0001-7606-7883
Madhi, Shabir A.0000-0002-7629-0636
Karp, Christopher L.0000-0002-0832-2659
Additional Information:© 2022 New York Academy of Sciences. Issue Online: 16 May 2022; Version of Record online: 14 January 2022; Manuscript accepted: 03 December 2021; Manuscript received: 03 December 2021. The authors declare no competing interests.
Subject Keywords:correlates of protection; COVID-19; human challenge studies; influenza; pneumococcal disease; streptococcus; vaccines; vaccine equity
Issue or Number:1
Record Number:CaltechAUTHORS:20220202-543652000
Persistent URL:
Official Citation:Cable, J., Rappuoli, R., Klemm, E.J., Kang, G., Mutreja, A., Wright, G.J., Pizza, M., Castro, S.A., Hoffmann, J.P., Alter, G., Carfi, A., Pollard, A.J., Krammer, F., Gupta, R.K., Wagner, C.E., Machado, V., Modjarrad, K., Corey, L., B. Gilbert, P., Dougan, G., Lurie, N., Bjorkman, P.J., Chiu, C., Nemes, E., Gordon, S.B., Steer, A.C., Rudel, T., Blish, C.A., Sandberg, J.T., Brennan, K., Klugman, K.P., Stuart, L.M., Madhi, S.A. and Karp, C.L. (2022), Innovative vaccine approaches—a Keystone Symposia report. Ann. N.Y. Acad. Sci., 1511: 59-86.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:113226
Deposited By: George Porter
Deposited On:03 Feb 2022 00:06
Last Modified:19 May 2022 16:58

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