CaltechAUTHORS
  A Caltech Library Service

An Ex Vivo Study of Outward Electrical Impedance Tomography (OEIT) for Intravascular Imaging

Luo, Yuan and Huang, Dong and Huang, Zi-Yu and Hsiai, Tzung K. and Tai, Yu-Chong (2022) An Ex Vivo Study of Outward Electrical Impedance Tomography (OEIT) for Intravascular Imaging. IEEE Transactions on Biomedical Engineering, 69 (2). pp. 734-745. ISSN 0018-9294. doi:10.1109/tbme.2021.3104300. https://resolver.caltech.edu/CaltechAUTHORS:20220204-680191000

[img] MS Word (supplementary figures S1-S5 with corresponding texts to further explain the content and their relevance to the main text) - Supplemental Material
See Usage Policy.

2MB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20220204-680191000

Abstract

Objective : Atherosclerosis is a chronic immuno-inflammatory condition emerging in arteries and considered the cause of a myriad of cardiovascular diseases. Atherosclerotic lesion characterization through invasive imaging modalities is essential in disease evaluation and determining intervention strategy. Recently, electrical properties of the lesions have been utilized in assessing its vulnerability mainly owing to its capability to differentiate lipid content existing in the lesion, albeit with limited detection resolution. Electrical impedance tomography is the natural extension of conventional spectrometric measurement by incorporating larger number of interrogating electrodes and advanced algorithm to achieve imaging of target objects and thus provides significantly richer information. It is within this context that we develop Outward Electrical Impedance Tomography (OEIT), aimed at intravascular imaging for atherosclerotic lesion characterization. Methods : We utilized flexible electronics to establish the 32-electrode OEIT device with outward facing configuration suitable for imaging of vessels. We conducted comprehensive studies through simulation model and ex vivo setup to demonstrate the functionality of OEIT. Results : Quantitative characterization for OEIT regarding its proximity sensing and conductivity differentiation was achieved using well-controlled experimental conditions. Imaging capability for OEIT was further verified with phantom setup using porcine aorta to emulate in vivo environment. Conclusion : We have successfully demonstrated a novel tool for intravascular imaging, OEIT, with unique advantages for atherosclerosis detection. Significance : This study demonstrates for the first time a novel electrical tomography-based platform for intravascular imaging, and we believe it paves the way for further adaptation of OEIT for intravascular detection in more translational settings and offers great potential as an alternative imaging tool for medical diagnosis.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/TBME.2021.3104300DOIArticle
ORCID:
AuthorORCID
Luo, Yuan0000-0003-3153-7495
Hsiai, Tzung K.0000-0003-1734-0792
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2021 IEEE. Manuscript received January 26, 2021; revised June 12, 2021; accepted August 3, 2021. Date of publication August 12, 2021; date of current version January 20, 2022. This work was supported in part by National Institute of Health under Grant R01HL118650, T.K.H and in part by China Postdoctoral Science Foundation under Grant 2019M660309, D.H. (Yuan Luo, Dong Huang and Zi-Yu Huang contributed equally to this work.) The authors want to thank Dr. Rene R. S. Packard and Dr. Parinaz Abiri for their helpful discussion throughout this work.
Funders:
Funding AgencyGrant Number
NIHR01HL118650
China Postdoctoral Science Foundation2019M660309
Subject Keywords:Atherosclerosis, electrical impedance tomography, intravascular imaging, intravascular navigation
Issue or Number:2
DOI:10.1109/tbme.2021.3104300
Record Number:CaltechAUTHORS:20220204-680191000
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220204-680191000
Official Citation:Y. Luo, D. Huang, Z. -Y. Huang, T. K. Hsiai and Y. -C. Tai, "An Ex Vivo Study of Outward Electrical Impedance Tomography (OEIT) for Intravascular Imaging," in IEEE Transactions on Biomedical Engineering, vol. 69, no. 2, pp. 734-745, Feb. 2022, doi: 10.1109/TBME.2021.3104300
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:113298
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:07 Feb 2022 15:22
Last Modified:07 Feb 2022 15:22

Repository Staff Only: item control page