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Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu, Yangzhi and Li, Shaopei and Li, Jinghang and Falcone, Natashya and Cui, Qingyu and Shah, Shilp and Hartel, Martin C. and Yu, Ning and Young, Patric and de Barros, Natan Roberto and Wu, Zhuohong and Haghniaz, Reihaneh and Ermis, Menekse and Wang, Canran and Kang, Heemin and Lee, Junmin and Karamikamkar, Solmaz and Ahadian, Samad and Jucaud, Vadim and Dokmeci, Mehmet R. and Kim, Han-Jun and Khademhosseini, Ali (2022) Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics. Advanced Materials, 34 (24). Art. No. 2108389. ISSN 0935-9648. PMCID PMC9233032. doi:10.1002/adma.202108389.

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The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed. First, the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications are discussed. Then, the latest advances in diagnostic and therapeutic SCLs for clinical translation are reviewed. Later, the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices are summarized. An outlook, future opportunities, and challenges for developing next-generation SCL devices are also provided. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

Item Type:Article
Related URLs:
URLURL TypeDescription
Zhu, Yangzhi0000-0003-2920-3365
de Barros, Natan Roberto0000-0001-8689-4110
Wang, Canran0000-0003-3297-9041
Kang, Heemin0000-0003-2694-9882
Dokmeci, Mehmet R.0000-0003-2226-9441
Kim, Han-Jun0000-0001-9238-7238
Khademhosseini, Ali0000-0002-2692-1524
Alternate Title:Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics
Additional Information:© 2022 Wiley-VCH GmbH. Issue Online: 16 June 2022; Version of Record online: 11 April 2022; Accepted manuscript online: 07 February 2022; Manuscript revised: 27 January 2022; Manuscript received: 19 October 2021. Y.Z., S.L., and J.L. contributed equally to this work. The authors gratefully acknowledged funding by the National Institutes of Health (CA214411, AR074234, GM126571, TR003148). Finally, the authors acknowledge our colleagues from the Terasaki Institute for Biomedical Innovation, the University of California, Los Angeles, the University of California, San Diego, and the University of California, Riverside, for the excellent collaboration. The authors declare no conflict of interest.
Funding AgencyGrant Number
Subject Keywords:bioelectronics; biosensors; contact lens; diagnostics; integrated systems; personalized healthcare; therapeutics; wearable electronics
Issue or Number:24
PubMed Central ID:PMC9233032
Record Number:CaltechAUTHORS:20220208-948192000
Persistent URL:
Official Citation:Zhu, Y., Li, S., Li, J., Falcone, N., Cui, Q., Shah, S., Hartel, M. C., Yu, N., Young, P., de, N. R., Wu, Z., Haghniaz, R., Ermis, M., Wang, C., Kang, H., Lee, J., Karamikamkar, S., Ahadian, S., Jucaud, V., Dokmeci, M. R., Kim, H.-J., Khademhosseini, A., Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics. Adv. Mater. 2022, 34, 2108389.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:113331
Deposited By: George Porter
Deposited On:08 Feb 2022 20:38
Last Modified:11 Jul 2022 23:04

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