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Observation of force-detected nuclear magnetic resonance in a homogeneous field

Madsen, L. A. and Leskowitz, G. M. and Weitekamp, D. P. (2004) Observation of force-detected nuclear magnetic resonance in a homogeneous field. Proceedings of the National Academy of Sciences of the United States of America, 101 (35). pp. 12804-12808. ISSN 0027-8424. PMCID PMC516476. doi:10.1073/pnas.0405232101.

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We report the experimental realization of BOOMERANG (better observation of magnetization, enhanced resolution, and no gradient), a sensitive and general method of magnetic resonance. The prototype millimeter-scale NMR spectrometer shows signal and noise levels in agreement with the design principles. We present H-1 and F-19 NMR in both solid and liquid samples, including time-domain Fourier transform NMR spectroscopy, multiple-pulse echoes, and heteronuclear J spectroscopy. By measuring a H-1-F-19 J coupling, this last experiment accomplishes chemically specific spectroscopy with force-detected NMR. In BOOMERANG, an assembly of permanent magnets provides a homogeneous field throughout the sample, while a harmonically suspended part of the assembly, a detector, is mechanically driven by spin-dependent forces. By placing the sample in a homogeneous field, signal dephasing by diffusion in a field gradient is made negligible, enabling application to liquids, in contrast to other force-detection methods. The design appears readily scalable to µm-scale samples where it should have sensitivity advantages over inductive detection with microcoils and where it holds great promise for application of magnetic resonance in biology, chemistry, physics, and surface science. We briefly discuss extensions of the BOOMERANG method to the µm and nm scales.

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Additional Information:© 2004 by the National Academy of Sciences. Communicated by John D. Roberts, California Institute of Technology, Pasadena, CA, July 19, 2004 (received for review May 29, 2003). Published online before print August 23, 2004, 10.1073/pnas.0405232101 This research was performed for the Center for Space Microelectronics Technology, Jet Propulsion Laboratory, California Institute of Technology, and was sponsored by the National Aeronautics and Space Administration, Office of Space Science.
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Subject Keywords:BOOMERANG spectrometry
Issue or Number:35
PubMed Central ID:PMC516476
Record Number:CaltechAUTHORS:MADpnas04
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1134
Deposited By: Tony Diaz
Deposited On:22 Dec 2005
Last Modified:08 Nov 2021 19:07

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