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Interhemispheric Coordination of Premotor Neural Activity during Singing in Adult Zebra Finches

Vu, Eric T. and Schmidt, Marc F. and Mazurek, Mark E. (1998) Interhemispheric Coordination of Premotor Neural Activity during Singing in Adult Zebra Finches. Journal of Neuroscience, 18 (21). pp. 9088-9098. ISSN 0270-6474. PMCID PMC6793527. doi:10.1523/jneurosci.18-21-09088.1998. https://resolver.caltech.edu/CaltechAUTHORS:20220223-204490000

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Abstract

The song system, a neural network that mediates the learning and production of song by oscine songbirds, is investigated extensively as a model system for understanding the neural basis of complex skill learning. Part of the complexity of birdsong arises from the coordinated recruitment of multiple groups of muscles on both sides of the body. Although the song system is bilaterally organized, little is known about how premotor activities on the two sides are coordinated during singing. We investigated this by unilaterally recording neural activity in the forebrain song nucleus HVc (also known as the high vocal center) during singing and by forcing the premotor activities in the two hemispheres out of synchrony by perturbing neural activity in the contralateral HVc with electrical stimulation. Perturbing the activity in one HVc at any time during a song led to a short-latency readjustment of activity in the contralateral HVc. This readjustment consisted of a true resetting of the temporal pattern of activity in the contralateral HVc rather than merely a transient activity suppression overlaid on an unaltered pattern of premotor activity. These results strongly suggest that the output of song premotor areas in the forebrain is continuously monitored and that an active mechanism exists for resynchronizing the outputs from the two hemispheres whenever their gross temporal patterns differ significantly. The possible anatomical substrates for these coordinating mechanisms and their potential roles in song learning are discussed.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/JNEUROSCI.18-21-09088.1998DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793527/PubMed CentralArticle
Additional Information:© 1998 Society for Neuroscience. Received April 9, 1998; revised Aug. 11, 1998; accepted Aug. 14, 1998. This work was supported by an Alfred P. Sloan fellowship to E.T.V. and by the following National Institutes of Health grants: the National Research Service Award (NRSA) NS08915 and R29 MH57065 to E.T.V. and the NRSA DC00125 and R03 DC03041 to M.F.S. We thank P. Drew and P. Sule for technical assistance and Drs. G. Laurent and M. Konishi for helpful comments on this manuscript. We also wish to thank M. Konishi for his generous support and for the use of his laboratory. Drs. E.T. Vu and M.F. Schmidt contributed equally to this paper.
Funders:
Funding AgencyGrant Number
Alfred P. Sloan FoundationUNSPECIFIED
NIH Predoctoral FellowshipNS08915
NIHR29 MH57065
NIH Predoctoral FellowshipDC00125
NIHR03 DC03041
Subject Keywords:birdsong; song system; zebra finch; interhemispheric coordination; song learning; motor coordination; motor learning
Issue or Number:21
PubMed Central ID:PMC6793527
DOI:10.1523/jneurosci.18-21-09088.1998
Record Number:CaltechAUTHORS:20220223-204490000
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220223-204490000
Official Citation:Interhemispheric Coordination of Premotor Neural Activity during Singing in Adult Zebra Finches Eric T. Vu, Marc F. Schmidt, Mark E. Mazurek Journal of Neuroscience 1 November 1998, 18 (21) 9088-9098; DOI: 10.1523/JNEUROSCI.18-21-09088.1998
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:113551
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:24 Feb 2022 21:18
Last Modified:24 Feb 2022 21:18

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