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Properties and hemispheric differences of theta oscillations in the human hippocampus

Penner, Cooper and Minxha, Juri and Chandravadia, Nand and Mamelak, Adam N. and Rutishauser, Ueli (2022) Properties and hemispheric differences of theta oscillations in the human hippocampus. Hippocampus, 32 (5). pp. 335-341. ISSN 1050-9631. doi:10.1002/hipo.23412. https://resolver.caltech.edu/CaltechAUTHORS:20220301-900055000

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Abstract

The left and right primate hippocampi (LH and RH) are thought to support distinct functions, but little is known about differences between the hemispheres at the neuronal level. We recorded single-neuron and local field potentials from the human hippocampus in epilepsy patients implanted with depth electrodes. We detected theta-frequency bouts of oscillatory activity while patients performed a visual recognition memory task. Theta appeared in bouts of 3.16 cycles, with sawtooth-shaped oscillations that had a prolonged downswing period. Outside the seizure onset zone, the average frequency of theta bouts was higher in the RH compared to the LH (6.0 vs. 5.3 Hz). LH theta bouts had lower amplitudes and a higher prevalence compared to the RH (26% vs. 21% of total time). Additionally, the RH contained a population of thin spiking visually tuned neurons that were not present in the LH. These data show that human theta appears in short oscillatory bouts whose properties vary between hemispheres, thereby revealing neurophysiological properties of the hippocampus that differ between the hemispheres.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/hipo.23412DOIArticle
https://doi.org/10.17605/OSF.IO/HV7JADOIData
ORCID:
AuthorORCID
Penner, Cooper0000-0002-6260-856X
Minxha, Juri0000-0003-4942-3269
Mamelak, Adam N.0000-0002-4245-6431
Rutishauser, Ueli0000-0002-9207-7069
Additional Information:© 2022 Wiley Periodicals LLC. Issue Online: 09 April 2022; Version of Record online: 01 March 2022; Manuscript accepted: 16 February 2022; Manuscript revised: 15 February 2022; Manuscript received: 10 August 2021. This study was supported by the National Science Foundation (BCS-1554105 to Ueli Rutishauser) and the National Institute of Health (R01MH110831, U01NS103792 to Ueli Rutishauser). The authors would like to thank the patients for their time and willingness to participate in this study, members of Rutishauser Lab for discussion, and the physicians and staff of the Epilepsy Monitoring Unit at Cedars-Sinai Medical Center for their support. Funding information: National Institute of Neurological Disorders and Stroke, Grant/Award Numbers: U01NS117839, U01NS103792; National Science Foundation (NSF), Grant/Award Number: BCS-1554105; National Institute of Mental Health, Grant/Award Number: R01MH110831/ The authors declare no conflict of interests. Data Availability Statement: The behavior and single-neuron data analyzed here are available in the standardized Neural data without Borders (NWB) format under 10.17605/OSF.IO/HV7JA. The LFP data are available from the corresponding author upon reasonable request.
Funders:
Funding AgencyGrant Number
NSFBCS-1554105
NIHR01MH110831
NIHU01NS103792
NIHU01NS117839
Subject Keywords:declarative memory; human hippocampus; intracranial; single neuron; theta oscillations
Issue or Number:5
DOI:10.1002/hipo.23412
Record Number:CaltechAUTHORS:20220301-900055000
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220301-900055000
Official Citation:Penner, C., Minxha, J., Chandravadia, N., Mamelak, A. N., & Rutishauser, U. (2022). Properties and hemispheric differences of theta oscillations in the human hippocampus. Hippocampus, 32(5), 335–341. https://doi.org/10.1002/hipo.23412
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:113670
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:02 Mar 2022 00:22
Last Modified:12 Apr 2022 20:23

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