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Biomineralization: Integrating mechanism and evolutionary history

Gilbert, Pupa U. P. A. and Bergmann, Kristin D. and Boekelheide, Nicholas and Tambutté, Sylvie and Mass, Tali and Marin, Frédéric and Adkins, Jess F. and Erez, Jonathan and Gilbert, Benjamin and Knutson, Vanessa and Cantine, Marjorie and Ortega Hernández, Javier and Knoll, Andrew H. (2022) Biomineralization: Integrating mechanism and evolutionary history. Science Advances, 8 (10). Art. No. abl9653. ISSN 2375-2548. PMCID PMC8906573. doi:10.1126/sciadv.abl9653.

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Calcium carbonate (CaCO₃) biomineralizing organisms have played major roles in the history of life and the global carbon cycle during the past 541 Ma. Both marine diversification and mass extinctions reflect physiological responses to environmental changes through time. An integrated understanding of carbonate biomineralization is necessary to illuminate this evolutionary record and to understand how modern organisms will respond to 21st century global change. Biomineralization evolved independently but convergently across phyla, suggesting a unity of mechanism that transcends biological differences. In this review, we combine CaCO₃ skeleton formation mechanisms with constraints from evolutionary history, omics, and a meta-analysis of isotopic data to develop a plausible model for CaCO₃ biomineralization applicable to all phyla. The model provides a framework for understanding the environmental sensitivity of marine calcifiers, past mass extinctions, and resilience in 21st century acidifying oceans. Thus, it frames questions about the past, present, and future of CaCO₃ biomineralizing organisms.

Item Type:Article
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URLURL TypeDescription Itemdata, the complete meta-analysis of carbon and oxygen isotope data and code CentralArticle
Gilbert, Pupa U. P. A.0000-0002-0139-2099
Bergmann, Kristin D.0000-0002-6106-2059
Boekelheide, Nicholas0000-0001-7296-9177
Tambutté, Sylvie0000-0002-0505-6375
Mass, Tali0000-0002-7298-290X
Marin, Frédéric0000-0001-8319-1735
Adkins, Jess F.0000-0002-3174-5190
Erez, Jonathan0000-0003-4616-0176
Gilbert, Benjamin0000-0003-0853-0826
Knutson, Vanessa0000-0001-9415-1384
Cantine, Marjorie0000-0002-9674-018X
Ortega Hernández, Javier0000-0002-6801-7373
Knoll, Andrew H.0000-0003-1308-8585
Additional Information:© 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). Received: 17 August 2021. Accepted: 6 January 2022. We thank the Radcliffe Institute for Advanced Study at Harvard University for funding and hosting the workshop “Biomineralization: integrating mechanism and evolutionary history” on 11 and 12 July 2019. All coauthors of this paper participated in intense discussions for 2 days in person and 2 years by email to achieve consensus. Thus, this paper is the direct result of that workshop. Thank you, Radcliffe! Author contributions: Conceptualization: P.U.P.A.G. and A.H.K. Methodology: P.U.P.A.G., K.D.B., and A.H.K. Meta-analysis: K.D.B. and N.B. Consensus model development: All coauthors. Writing—original draft: P.U.P.A.G., K.D.B., and A.H.K. Writing—review and editing: All coauthors. The authors declare that they have no financial or other competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper, including the complete meta-analysis of carbon and oxygen isotope data and code, are available in the public domain on and cited as (241).
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Radcliffe Institute for Advanced StudyUNSPECIFIED
Issue or Number:10
PubMed Central ID:PMC8906573
Record Number:CaltechAUTHORS:20220309-982087000
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Official Citation:Biomineralization: Integrating mechanism and evolutionary history. Pupa U. P. A. Gilbert, Kristin D. Bergmann, Nicholas Boekelheide, Sylvie Tambutté, Tali Mass, Frédéric Marin, Jess F. Adkins, Jonathan Erez, Benjamin Gilbert, Vanessa Knutson, Marjorie Cantine, Javier Ortega Hernández, Andrew H. Knoll. Sci. Adv., 8 (10), eabl9653; DOI: 10.1126/sciadv.abl9653
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:113809
Deposited By: George Porter
Deposited On:09 Mar 2022 21:37
Last Modified:23 Mar 2022 19:18

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