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The emerging role of photoacoustic imaging in clinical oncology

Lin, Li and Wang, Lihong V. (2022) The emerging role of photoacoustic imaging in clinical oncology. Nature Reviews Clinical Oncology, 19 (6). pp. 365-384. ISSN 1759-4774. doi:10.1038/s41571-022-00615-3. https://resolver.caltech.edu/CaltechAUTHORS:20220324-205710950

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Abstract

Clinical oncology can benefit substantially from imaging technologies that reveal physiological characteristics with multiscale observations. Complementing conventional imaging modalities, photoacoustic imaging (PAI) offers rapid imaging (for example, cross-sectional imaging in real time or whole-breast scanning in 10–15 s), scalably high levels of spatial resolution, safe operation and adaptable configurations. Most importantly, this novel imaging modality provides informative optical contrast that reveals details on anatomical, functional, molecular and histological features. In this Review, we describe the current state of development of PAI and the emerging roles of this technology in cancer screening, diagnosis and therapy. We comment on the performance of cutting-edge photoacoustic platforms, and discuss their clinical applications and utility in various clinical studies. Notably, the clinical translation of PAI is accelerating in the areas of macroscopic and mesoscopic imaging for patients with breast or skin cancers, as well as in microscopic imaging for histopathology. We also highlight the potential of future developments in technological capabilities and their clinical implications, which we anticipate will lead to PAI becoming a desirable and widely used imaging modality in oncological research and practice.


Item Type:Article
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https://doi.org/10.1038/s41571-022-00615-3DOIArticle
https://rdcu.be/cJKSQPublisherFree ReadCube access
ORCID:
AuthorORCID
Lin, Li0000-0002-0517-8436
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2022 Nature Publishing Group. Accepted 23 February 2022; Published 23 March 2022. The authors thank R. Cao for useful discussions. The authors are also grateful to J. Ballard, D. Garrett and J. Olick-Gibson for close reading of the paper. Contributions: Both authors made substantial contributions to all aspects of the preparation of this manuscript. Competing interests: L.V.W. has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC and Union Photoacoustic Technologies, Ltd., which, however, did not support this work. L.L. declares no competing interests. Peer review information: Nature Reviews Clinical Oncology thanks the anonymous reviewer(s) for their contribution to the peer review of this work.
Subject Keywords:Breast cancer; Cancer imaging; Cancer screening; Prostate cancer; Skin cancer
Issue or Number:6
DOI:10.1038/s41571-022-00615-3
Record Number:CaltechAUTHORS:20220324-205710950
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220324-205710950
Official Citation:Lin, L., Wang, L.V. The emerging role of photoacoustic imaging in clinical oncology. Nat Rev Clin Oncol 19, 365–384 (2022). https://doi.org/10.1038/s41571-022-00615-3
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:114064
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Mar 2022 21:58
Last Modified:24 May 2022 17:58

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