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Functional Cell Types in the Mouse Superior Colliculus

Li, Ya-tang and Meister, Markus (2022) Functional Cell Types in the Mouse Superior Colliculus. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20220406-729141742

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Abstract

The superior colliculus (SC) represents a major visual processing station in the mammalian brain that receives input from many types of retinal ganglion cells (RGCs). How many parallel channels exist in the SC, and what information does each encode? Here we recorded from mouse superficial SC neurons under a battery of visual stimuli including those used for classification of RGCs. An unsupervised clustering algorithm identified 24 functional types based on their visual responses. They fall into two groups: one that responds similarly to RGCs, and another with more diverse and specialized stimulus selectivity. The second group is dominant at greater depths, consistent with a vertical progression of signal processing in the SC. Cells of the same functional type tend to cluster near each other in anatomical space. Compared to the retina, the visual representation in the SC has lower dimensionality, consistent with a sifting process along the visual pathway.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/2022.04.01.486789DOIDiscussion Paper
ORCID:
AuthorORCID
Li, Ya-tang0000-0003-2763-1534
Meister, Markus0000-0003-2136-6506
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. Version 1 - April 5, 2022; Version 2 - August 1, 2022. M.M. was supported by grants from NIH (R01 NS111477) and from the Simons Foundation (543015SPI). Y.-t.L was supported by a grant from the NEI (K99EY028640) and a Helen Hay Whitney Postdoctoral Fellowship. Author contributions: Y.-t.L designed the study, performed all experiments, interpreted results, and wrote the manuscript. M.M. helped design the study, interpret results, and write the manuscript. The authors declare no competing interests. Data and code availability: Data and code will be available in a public repository following acceptance of the manuscript.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funders:
Funding AgencyGrant Number
NIHR01 NS111477
Simons Foundation543015SPI
National Eye InstituteK99EY028640
Helen Hay Whitney FoundationUNSPECIFIED
DOI:10.1101/2022.04.01.486789
Record Number:CaltechAUTHORS:20220406-729141742
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220406-729141742
Official Citation:Functional Cell Types in the Mouse Superior Colliculus. Ya-tang Li, Markus Meister. bioRxiv 2022.04.01.486789; doi: https://doi.org/10.1101/2022.04.01.486789
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:114181
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:06 Apr 2022 13:36
Last Modified:26 Aug 2022 23:12

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