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Structural insights into antibody-mediated neutralization of SARS-CoV-2

Barnes, Christopher and Scheid, Johannes F. and Eraslan, Basak and Hudak, Andrew and Muecksch, Frauke and Weisblum, Yiska and Bjorkman, Pamela J. and Xavier, Ramnik J. (2021) Structural insights into antibody-mediated neutralization of SARS-CoV-2. Glycobiology, 31 (12). pp. 1696-1697. ISSN 0959-6658. doi:10.1093/glycob/cwab121.

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In less than a year, researchers have uncovered structure–function details for many of the proteins encoded by SARS-CoV-2. We report structures that reveal how monoclonal neutralizing antibodies bind spike to prevent infection. One such monoclonal antibody, BG10–19, targets a highly-conserved, proteoglycan epitope on the SARS-CoV-2 RBD, which sits outside of mutated residue positions found in all circulating variants of concern (i.e. alpha, beta, gamma, delta, kappa, and lambda). In addition, BG10–19 bridges adjacent RBDs and locks the spike trimer in a completely closed conformation to potently neutralize SARSCoV-2 and heterologous SARS-like coronaviruses. Thus, BG10–19 is a candidate antibody therapeutic to combat continuing SARS-CoV-2 antigenic drift and represents an attractive epitope for pan-sarbecovirus vaccine design.

Item Type:Article
Related URLs:
URLURL TypeDescription
Barnes, Christopher0000-0003-2754-5951
Eraslan, Basak0000-0003-3698-8279
Hudak, Andrew0000-0002-0241-2290
Muecksch, Frauke0000-0002-0132-5101
Weisblum, Yiska0000-0002-9249-1745
Bjorkman, Pamela J.0000-0002-2277-3990
Xavier, Ramnik J.0000-0002-5630-5167
Additional Information:© The Author(s) 2021. Published by Oxford University Press. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Published: 27 January 2022.
Issue or Number:12
Record Number:CaltechAUTHORS:20220415-214637408
Persistent URL:
Official Citation:Program and Abstracts for the 2021 Annual Meeting of the Society for Glycobiology, Glycobiology, Volume 31, Issue 12, December 2021, Pages 1670–1776,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:114351
Deposited By: Tony Diaz
Deposited On:18 Apr 2022 16:58
Last Modified:18 Apr 2022 16:58

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