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Growth Responses of a Sulfonamide-requiring Mutant Strain of Neurospora

Emerson, Sterling (1947) Growth Responses of a Sulfonamide-requiring Mutant Strain of Neurospora. Journal of Bacteriology, 54 (2). pp. 195-207. ISSN 0021-9193. PMCID PMC526537.

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A mutant strain of Neurospora crassa has appeared in which the antagonistic roles of p-aminobenzoic acid and the sulfonamides have been reversed to a considerable extent. Optimal growth of this strain occurs only in the presence of sulfonamides. Conversely, p-aminobenzoic acid is a potent fungistatic agent for this strain under certain conditions. To say that sulfanilamide has become an essential metabolite and p-aminobenzoic acid an inhibiting analog would be to oversimplify the altered physiology of this mutant strain. It will be shown that, in this strain, both sulfonamides and p-aminobenzoic acid are essential for growth, and that each acts as an inhibiting analog of the other. These interrelations are further complicated by the effect of temperature on the need for sulfonamides, and on the inhibition by p-aminobenzoic acid. The present report deals exclusively with the growth responses of this mutant strain to sulfonamides, to temperature, and to p-aminobenzoic acid. At the present time nothing definite is known of the physiological role of sulfonamides in this strain.

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Additional Information:© 1947 American Society for Microbiology. Received for publication May 6, 1947. Representing work supported in part by a grant from the Rockefeller Foundation, and in part by a grant from the American Cancer Society on the recommendation of the Committee on Growth of the National Research Council. With the technical assistance of Mary R. Emerson and Lydia Hawk.
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Rockefeller FoundationUNSPECIFIED
American Cancer SocietyUNSPECIFIED
Issue or Number:2
PubMed Central ID:PMC526537
Record Number:CaltechAUTHORS:EMEjbact47
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11441
Deposited By: Archive Administrator
Deposited On:14 Aug 2008 23:47
Last Modified:03 Oct 2019 00:19

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