CaltechAUTHORS
  A Caltech Library Service

Innovation by evolution: bringing new chemistry to life

Arnold, Frances H. (2022) Innovation by evolution: bringing new chemistry to life. Biophysical Journal, 121 (3). 177a. ISSN 0006-3495. doi:10.1016/j.bpj.2021.11.1846. https://resolver.caltech.edu/CaltechAUTHORS:20220422-230413893

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20220422-230413893

Abstract

Not satisfied with biology's vast catalyst repertoire, I want to create new enzyme catalysts and expand the chemistry of life. We use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones, thereby circumventing our profound ignorance of how sequence encodes function. Chemistry encoded in DNA and optimized by evolution enables efficient, sustainable routes to important fuels and chemicals. Evolution not only optimizes, it can also innovate and create entirely new enzyme catalysts. I will illustrate how whole families of new-to-nature enzymes increase the scope of molecules and materials that can be built using synthetic biology.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.bpj.2021.11.1846DOIArticle
ORCID:
AuthorORCID
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 2021 Biophysical Society. Published by Elsevier Inc. Available online 11 February 2022, Version of Record 11 February 2022.
Issue or Number:3
DOI:10.1016/j.bpj.2021.11.1846
Record Number:CaltechAUTHORS:20220422-230413893
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220422-230413893
Official Citation:Frances H. Arnold, Innovation by evolution: bringing new chemistry to life, Biophysical Journal, Volume 121, Issue 3, Supplement 1, 2022, Page 177a, ISSN 0006-3495, https://doi.org/10.1016/j.bpj.2021.11.1846.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:114438
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Apr 2022 18:30
Last Modified:25 Apr 2022 18:30

Repository Staff Only: item control page