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Systems Level Model of Dietary Effects on Cognition via the Microbiome-Gut-Brain Axis

Mayalu, Michaëlle N. and Sarma, Anish and Xiao, Fangzhou and Doyle, John C. and Murray, Richard M. (2021) Systems Level Model of Dietary Effects on Cognition via the Microbiome-Gut-Brain Axis. In: 2021 European Control Conference (ECC). IEEE , Piscataway, NJ, pp. 312-318. ISBN 978-9-4638-4236-5.

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Intercommunication of the microbiome-gut-brain axis occurs through various signaling pathways including the vagus nerve, immune system, endocrine/paracrine, and bacteria-derived metabolites. But how these pathways integrate to influence cognition remains undefined. In this paper, we create a systems level mathematical framework comprised of interconnected organ-level dynamical subsystems to increase conceptual understanding of how these subsystems contribute to cognitive performance. With this framework we propose that control of hippocampal long-term potentiation (hypothesized to correlate with cognitive performance) is influenced by interorgan signaling with diet as the external control input. Specifically, diet can influence synaptic strength (LTP) homeostatic conditions necessary for learning. The proposed model provides new qualitative information about the functional relationship between diet and output cognitive performance. The results can give insight for optimization of cognitive performance via diet in experimental animal models.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Mayalu, Michaëlle N.0000-0002-9678-0157
Sarma, Anish0000-0003-1261-0589
Xiao, Fangzhou0000-0002-5001-5644
Doyle, John C.0000-0002-1828-2486
Murray, Richard M.0000-0002-5785-7481
Additional Information:© 2021 EUCA. This work was supported by Army Research Office (ARO) MURI contract no. W911NF-17-1-0402. We thank collaborators Elaine Hsiao (UCLA) and Christine Olson (UCLA) for helpful discussions.
Funding AgencyGrant Number
Army Research Office (ARO)W911NF-17-1-0402
Record Number:CaltechAUTHORS:20220503-50866100
Persistent URL:
Official Citation:M. N. Mayalu, A. Sarma, F. Xiao, J. C. Doyle and R. M. Murray, "Systems Level Model of Dietary Effects on Cognition via the Microbiome-Gut-Brain Axis," 2021 European Control Conference (ECC), 2021, pp. 312-318, doi: 10.23919/ECC54610.2021.9655216
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:114560
Deposited By: Tony Diaz
Deposited On:03 May 2022 21:36
Last Modified:03 May 2022 21:36

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