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Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

Wang, Canran and Jiang, Xing and Kim, Han-Jun and Zhang, Shiming and Zhou, Xingwu and Chen, Yi and Ling, Haonan and Xue, Yumeng and Chen, Zhaowei and Qu, Moyuan and Ren, Li and Zhu, Jixiang and Libanori, Alberto and Zhu, Yangzhi and Kang, Heemin and Ahadian, Samad and Dokmeci, Mehmet R. and Servati, Peyman and He, Ximin and Gu, Zhen and Sun, Wujin and Khademhosseini, Ali (2022) Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing. Biomaterials, 285 . Art. No. 121479. ISSN 0142-9612. doi:10.1016/j.biomaterials.2022.121479.

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Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound microenvironment. In vitro studies indicated an elevated secretion of growth factors with enhanced cell proliferation and migration ability in response to electrical stimulation. An in vivo study in the Sprague-Dawley rat model revealed a rapid wound closure within 7 days compared to 20 days of usual healing process in rodents.

Item Type:Article
Related URLs:
URLURL TypeDescription Information
Kim, Han-Jun0000-0001-9238-7238
Zhou, Xingwu0000-0001-5977-2185
Chen, Yi0000-0001-5329-4987
Libanori, Alberto0000-0003-1913-3017
Zhu, Yangzhi0000-0003-2920-3365
Kang, Heemin0000-0003-2694-9882
Dokmeci, Mehmet R.0000-0003-2226-9441
Sun, Wujin0000-0002-3167-111X
Khademhosseini, Ali0000-0002-2692-1524
Additional Information:© 2022 Elsevier Ltd. Received 3 November 2021, Revised 7 March 2022, Accepted 18 March 2022, Available online 14 April 2022, Version of Record 26 April 2022. The authors acknowledge funding from the National Institutes of Health (EB024403, EB023052, GM126831, and HL140618). Data availability: The experimental data required to reproduce the findings from this study will be made available to interested investigators upon request. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Funding AgencyGrant Number
Subject Keywords:Wearable device; Electrical stimulation; Wound healing; Conductive hydrogel; Antibacteria
Record Number:CaltechAUTHORS:20220511-997844500
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Official Citation:Canran Wang, Xing Jiang, Han-Jun Kim, Shiming Zhang, Xingwu Zhou, Yi Chen, Haonan Ling, Yumeng Xue, Zhaowei Chen, Moyuan Qu, Li Ren, Jixiang Zhu, Alberto Libanori, Yangzhi Zhu, Heemin Kang, Samad Ahadian, Mehmet R. Dokmeci, Peyman Servati, Ximin He, Zhen Gu, Wujin Sun, Ali Khademhosseini, Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing, Biomaterials, Volume 285, 2022, 121479, ISSN 0142-9612,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:114682
Deposited By: Tony Diaz
Deposited On:11 May 2022 21:07
Last Modified:11 May 2022 21:07

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