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Preserved cortical somatotopic and motor representations in tetraplegic humans

Andersen, Richard A. and Aflalo, Tyson (2022) Preserved cortical somatotopic and motor representations in tetraplegic humans. Current Opinion in Neurobiology, 74 . Art. No. 102547. ISSN 0959-4388. doi:10.1016/j.conb.2022.102547.

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A rich literature has documented changes in cortical representations of the body in somatosensory and motor cortex. Recent clinical studies of brain–machine interfaces designed to assist paralyzed patients have afforded the opportunity to record from and stimulate human somatosensory, motor, and action-related areas of the posterior parietal cortex. These studies show considerable preserved structure in the cortical somato-motor system. Motor cortex can immediately control assistive devices, stimulation of somatosensory cortex produces sensations in an orderly somatotopic map, and the posterior parietal cortex shows a high-dimensional representation of cognitive action variables. These results are strikingly similar to what would be expected in a healthy subject, demonstrating considerable stability of adult cortex even after severe injury and despite potential plasticity-induced new activations within the same region of cortex. Clinically, these results emphasize the importance of targeting cortical areas for BMI control signals that are consistent with their normal functional role.

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Andersen, Richard A.0000-0002-7947-0472
Aflalo, Tyson0000-0002-0101-2455
Additional Information:© 2022 The Authors. Published by Elsevier. Under a Creative Commons license - Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Available online 6 May 2022, Version of Record 6 May 2022. This review comes from a themed issue on Neuroscience of Somatosensation; Edited by Miriam Goodman and Diana Bautista. We would like to thank Charles Guan for feedback on this manuscript. This work was supported by the NIH (R01EY015545, UG1EY032039), the Tianqiao and Chrissy Chen Brain-machine Interface Center at Caltech, and the Boswell Foundation. Conflict of interest statement: Nothing declared.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
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Tianqiao and Chrissy Chen Institute for NeuroscienceUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20220513-557982000
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Official Citation:Richard A. Andersen, Tyson Aflalo, Preserved cortical somatotopic and motor representations in tetraplegic humans, Current Opinion in Neurobiology, Volume 74, 2022, 102547, ISSN 0959-4388,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:114750
Deposited By: George Porter
Deposited On:13 May 2022 22:09
Last Modified:13 May 2022 22:09

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