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Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders

Gubert, Carolina and Gasparotto, Juciano and Morais, Livia H. (2022) Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders. Gastroenterology Report, 10 . Art. No. goac017. ISSN 2052-0034. PMCID PMC9109005. doi:10.1093/gastro/goac017.

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Recent research has been uncovering the role of the gut microbiota for brain health and disease. These studies highlight the role of gut microbiota on regulating brain function and behavior through immune, metabolic, and neuronal pathways. In this review we provide an overview of the gut microbiota axis pathways to lay the groundwork for upcoming sessions on the links between the gut microbiota and neurogenerative disorders. We also discuss how the gut microbiota may act as an intermediate factor between the host and the environment to mediate disease onset and neuropathology. Based on the current literature, we further examine the potential for different microbiota-based therapeutic strategies to prevent, to modify, or to halt the progress of neurodegeneration.

Item Type:Article
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URLURL TypeDescription CentralArticle
Gubert, Carolina0000-0002-8078-1390
Gasparotto, Juciano0000-0003-2545-7288
Morais, Livia H.0000-0002-5738-2658
Additional Information:© The Author(s) 2022. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Received: 23 January 2022. Revision received: 22 March 2022. Accepted: 01 April 2022. Published: 16 May 2022. C.G. is a Hereditary Disease Foundation (HDF) Fellow. L.H.M. is a postdoctoral scholar at Caltech and recipient of the American Parkinson’s Disease Association postdoctoral fellowship. Carolina Gubert and Juciano Gasparotto contributed equally to this work. Authors’ Contributions. All the authors contributed substantially to discussions of the article content and to the writing. L.H.M. conceived of the idea and coordinated the study. All authors read and approved the final manuscript. Conflict of Interest: None declared.
Funding AgencyGrant Number
Hereditary Disease FoundationUNSPECIFIED
American Parkinson’s Disease AssociationUNSPECIFIED
Subject Keywords:gut microbiota–brain axis, neurodegeneration, inflammation, microbial metabolism, gut microbiota
PubMed Central ID:PMC9109005
Record Number:CaltechAUTHORS:20220519-375143000
Persistent URL:
Official Citation:Carolina Gubert, Juciano Gasparotto, Livia H. Morais, Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders, Gastroenterology Report, Volume 10, 2022, goac017,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:114810
Deposited By: George Porter
Deposited On:19 May 2022 23:22
Last Modified:20 May 2022 15:55

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