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Loss of famh-136/ FAM136A results in minor locomotion and behavioral changes in Caenorhabditis elegans

Tan, Chieh-Hsiang and Park, Heenam and Sternberg, Paul W. (2022) Loss of famh-136/ FAM136A results in minor locomotion and behavioral changes in Caenorhabditis elegans. microPublication Biology, 2022 . Art. No. 000553. ISSN 2578-9430. PMCID PMC9163966. https://resolver.caltech.edu/CaltechAUTHORS:20220607-425206000

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Abstract

The human gene FAM136A (family with sequence similarity 136 member A) has been associated with familial Meniere’s disease (MD) (Requena et al., 2015), a chronic disorder of the inner ear (Nakashima et al., 2016). There is also a suggestion that the expression of the gene could be associated with lung cancer prognosis (Zhao et al., 2020). FAM136A is evolutionary conserved, with orthologs identified in various metazoan species (Alliance of Genome Resources, 2022). However, with the exception of some expression data and omics level analysis (Alliance of Genome Resources, 2022; Stuckenholz et al., 2009), very little is known about FAM136A.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.17912/micropub.biology.000553DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163966/PubMed CentralArticle
ORCID:
AuthorORCID
Tan, Chieh-Hsiang0000-0002-5432-0160
Park, Heenam0000-0001-7911-5828
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2022 by the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received: 3/26/2022. Revision Received: 4/23/2022. Accepted: 5/30/2022. Published: 6/2/2022. We thank Tsui-Fen Chou for providing Cas9 protein and Wan-Rong Wong for experimental and technical advice. We would also like to thank all members of the Sternberg lab for experimental support and discussions. This work was supported by NIH grants R24OD023041 and R01 HD086596 (PWS). Funding: NIH grants R24OD023041 and R01 HD086596 (PWS). Author Contributions. Chieh-Hsiang Tan: Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing - original draft, Writing - review & editing Heenam Park: Investigation, Resources, Writing - review & editing Paul W. Sternberg: Conceptualization, Funding acquisition, Supervision, Writing - review & editing
Funders:
Funding AgencyGrant Number
NIHR24OD023041
NIHR01 HD086596
PubMed Central ID:PMC9163966
Record Number:CaltechAUTHORS:20220607-425206000
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220607-425206000
Official Citation:Tan, CH; Park, H; Sternberg, PW (2022). Loss of famh-136/ FAM136A results in minor locomotion and behavioral changes in Caenorhabditis elegans. microPublication Biology. 10.17912/micropub.biology.000553.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:115051
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:07 Jun 2022 23:34
Last Modified:25 Jul 2022 23:14

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