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Recording advances for neural prosthetics

Andersen, R. A. and Burdick, J. W. and Musallam, S. and Scherberger, H. and Pesaran, B. and Meeker, D. and Corneil, B. D. and Fineman, I. and Nenadic, Z. and Branchaud, E. and Cham, J. G. and Greger, B. and Tai, Y. C. and Mojarradi, M. M. (2004) Recording advances for neural prosthetics. In: IEEE Engineering in Medicine and Biology Society, 26th Annual International Conference. IEMBS '04, 1-5 September 2004, San Francisco, CA. Vol.7. IEEE , Piscataway, NJ, pp. 5352-5355. ISBN 0-7803-8439-3.

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An important challenge for neural prosthetics research is to record from populations of neurons over long periods of time, ideally for the lifetime of the patient. Two new advances toward this goal are described, the use of local field potentials (LFPs) and autonomously positioned recording electrodes. LFPs are the composite extracellular potential field from several hundreds of neurons around the electrode tip. LFP recordings can be maintained for longer periods of time than single cell recordings. We find that similar information can be decoded from LFP and spike recordings, with better performance for state decodes with LFPs and, depending on the area, equivalent or slightly less than equivalent performance for signaling the direction of planned movements. Movable electrodes in microdrives can be adjusted in the tissue to optimize recordings, but their movements must be automated to be a practical benefit to patients. We have developed automation algorithms and a meso-scale autonomous electrode testbed, and demonstrated that this system can autonomously isolate and maintain the recorded signal quality of single cells in the cortex of awake, behaving monkeys. These two advances show promise for developing very long term recording for neural prosthetic applications.

Item Type:Book Section
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URLURL TypeDescription
Andersen, R. A.0000-0002-7947-0472
Greger, B.0000-0002-6702-7596
Tai, Y. C.0000-0001-8529-106X
Additional Information:© 2004 IEEE. Reprinted with permission. We thank Tessa Yao for administrative support, Betty Grieve, Kelsie Pejsa, and Lea Martel for technical support, and Viktor Shcherbatyuk for computer support. We wish to acknowledge the support of the Defense Advanced Research Projects Agency, the National Eye Institute, the Office of Naval Research, the Boswell Foundation, the National Science Foundation, the Christopher Reeve Paralysis Foundation, and the Human Frontier Science Program.
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
National Eye InstituteUNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Christopher Reeve Paralysis FoundationUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Subject Keywords:Neural Prosthetics; LFP; Movable Electrodes; bioelectric potentials; biological tissues; biomedical electrodes; brain; neurophysiology; prosthetics; automation algorithms; cortex; local field potentials; monkeys; neural prosthetics; neurons; spike recordings
Record Number:CaltechAUTHORS:ANDembc04
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ID Code:11511
Deposited On:26 Aug 2008 23:11
Last Modified:08 Nov 2021 22:00

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