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Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction

Glynn, Allison T. and Davidson, Samuel R. and Qian, Lulu (2022) Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction. Journal of the American Chemical Society, 144 (22). pp. 10075-10079. ISSN 0002-7863. PMCID PMC9185747. doi:10.1021/jacs.2c03853. https://resolver.caltech.edu/CaltechAUTHORS:20220614-222121000

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Abstract

Developmental self-assembly of DNA nanostructures provides an ideal platform for studying the power and programmability of kinetically controlled structural growth in engineered molecular systems. Triggered initiation and designated sequencing of assembly and disassembly steps have been demonstrated in structures with branches and loops. Here we introduce a new strategy for selectively activating distinct subroutines in a developmental self-assembly program, allowing structures with distinct properties to be created in response to various molecular signals. We demonstrate this strategy in triggered self-assembly of a DNA ring, the size and growth direction of which are responsive to a key molecule. We articulate that reversible assembly steps with slow kinetics at appropriate locations in a reaction pathway could enable multiple populations of structures with stimulus-responsive properties to be simultaneously created in one developmental program. These results open up a broad design space for the self-assembly of molecules with adaptive behaviors toward advanced control in synthetic materials and molecular motors.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/jacs.2c03853DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185747/PubMed CentralArticle
ORCID:
AuthorORCID
Davidson, Samuel R.0000-0002-8081-3591
Qian, Lulu0000-0003-4115-2409
Additional Information:© 2022 The Authors. Published by American Chemical Society. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). Received 10 April 2022. Published online 26 May 2022. Published in issue 8 June 2022. A.T.G. and S.R.D. were supported by Caltech internal funds for BE/CS 196, a course on the design and construction of programmable molecular systems. S.R.D. was also supported by a NIH/BLP training grant (5 T32 GM 112592-5). L.Q. was supported by a NSF award (1813550). The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
CaltechUNSPECIFIED
NIH Predoctoral Fellowship5 T32 GM 112592-5
NSFCCF-1813550
Subject Keywords:Chemical structure, Fluorescence, Genetics, Kinetics, Self organization
Issue or Number:22
PubMed Central ID:PMC9185747
DOI:10.1021/jacs.2c03853
Record Number:CaltechAUTHORS:20220614-222121000
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220614-222121000
Official Citation:Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction Allison T. Glynn, Samuel R. Davidson, and Lulu Qian Journal of the American Chemical Society 2022 144 (22), 10075-10079 DOI: 10.1021/jacs.2c03853
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:115145
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:15 Jun 2022 16:36
Last Modified:15 Jun 2022 16:36

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