Forced entry into the nucleus

Petrovic, Stefan and Hoelz, André (2022) Forced entry into the nucleus. Nature Cell Biology, 24 (6). pp. 810-812. ISSN 1465-7392. PMCID PMC9348904. doi:10.1038/s41556-022-00939-3. https://resolver.caltech.edu/CaltechAUTHORS:20220615-392838600

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Abstract

The nuclear pore complex (NPC) regulates transport of macromolecules into and out of the nucleus. A study now shows that mechanical force applied on the nucleus affects the transport rates across the NPC diffusion barrier, modulating the nuclear localization of certain cargos.

Item Type:

Article

Related URLs:

URL	URL Type	Description
https://doi.org/10.1038/s41556-022-00939-3	DOI	Article
https://rdcu.be/cPIig	Publisher	Free ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348904	PubMed Central	Article

ORCID:

Author	ORCID
Petrovic, Stefan	0000-0002-4979-8696
Hoelz, André	0000-0003-1726-0127

Additional Information:

Funders:

Funding Agency	Grant Number
Howard Hughes Medical Institute (HHMI)	55108534
NIH	GM117360
NIH	GM111461

Subject Keywords:

Mechanotransduction; Nuclear pore complex; Protein translocation

Issue or Number:

PubMed Central ID:

PMC9348904

DOI:

10.1038/s41556-022-00939-3

Record Number:

CaltechAUTHORS:20220615-392838600

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20220615-392838600

Official Citation:

Petrovic, S., Hoelz, A. Forced entry into the nucleus. Nat Cell Biol 24, 810–812 (2022). https://doi.org/10.1038/s41556-022-00939-3

Usage Policy:

No commercial reproduction, distribution, display or performance rights in this work are provided.

ID Code:

115167

Collection:

CaltechAUTHORS

Deposited By:

Tony Diaz

Deposited On:

17 Jun 2022 19:19

Last Modified:

16 Aug 2022 22:03

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