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Forced entry into the nucleus

Petrovic, Stefan and Hoelz, André (2022) Forced entry into the nucleus. Nature Cell Biology, 24 (6). pp. 810-812. ISSN 1465-7392. PMCID PMC9348904. doi:10.1038/s41556-022-00939-3. https://resolver.caltech.edu/CaltechAUTHORS:20220615-392838600

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Abstract

The nuclear pore complex (NPC) regulates transport of macromolecules into and out of the nucleus. A study now shows that mechanical force applied on the nucleus affects the transport rates across the NPC diffusion barrier, modulating the nuclear localization of certain cargos.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/s41556-022-00939-3DOIArticle
https://rdcu.be/cPIigPublisherFree ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348904PubMed CentralArticle
ORCID:
AuthorORCID
Petrovic, Stefan0000-0002-4979-8696
Hoelz, André0000-0003-1726-0127
Additional Information:© 2022 Nature Publishing Group. Published 09 June 2022. The authors declare no competing interests.
Funders:
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)55108534
NIHGM117360
NIHGM111461
Subject Keywords:Mechanotransduction; Nuclear pore complex; Protein translocation
Issue or Number:6
PubMed Central ID:PMC9348904
DOI:10.1038/s41556-022-00939-3
Record Number:CaltechAUTHORS:20220615-392838600
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220615-392838600
Official Citation:Petrovic, S., Hoelz, A. Forced entry into the nucleus. Nat Cell Biol 24, 810–812 (2022). https://doi.org/10.1038/s41556-022-00939-3
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:115167
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Jun 2022 19:19
Last Modified:16 Aug 2022 22:03

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