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Transcranial photoacoustic computed tomography of human brain function

Zhang, Yang and Na, Shuai and Sastry, Karteekeya and Russin, Jonathan J. and Hu, Peng and Lin, Li and Tong, Xin and Jann, Kay B. and Wang, Danny J. and Liu, Charles Y. and Wang, Lihong V. (2022) Transcranial photoacoustic computed tomography of human brain function. . (Unpublished)

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Herein we report the first in-human transcranial imaging of brain function using photoacoustic computed tomography. Functional responses to benchmark motor tasks were imaged on both the skull-less and the skull-intact hemispheres of a hemicraniectomy patient. The observed brain responses in these preliminary results demonstrate the potential of photoacoustic computed tomography for achieving transcranial functional imaging.

Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription Paper
Zhang, Yang0000-0002-4168-9225
Na, Shuai0000-0003-2083-0047
Sastry, Karteekeya0000-0001-7659-4878
Russin, Jonathan J.0000-0002-5304-4977
Hu, Peng0000-0002-2933-1239
Lin, Li0000-0002-0517-8436
Jann, Kay B.0000-0003-3574-0538
Wang, Danny J.0000-0002-0840-7062
Liu, Charles Y.0000-0001-6423-8577
Wang, Lihong V.0000-0001-9783-4383
Additional Information:We thank former lab members Konstantin Maslov, Xiaoyun Yuan, and Junhui Shi for their contribution towards building the system. This work was sponsored by the United States National Institutes of Health (NIH) grants U01 NS099717 (BRAIN Initiative), S10-OD025312, R01 NS102213, and R35 CA220436. Contributions. L.V.W., C.Y.L., Y.Z., S.N. and J.J.R. designed the study. L.L., S.N., Y.Z., and X.T. built and modified the system hardware. S.N. and Y.Z. developed and modified the control program. P.H., and S.N. developed the structural and functional reconstruction algorithms. Y.Z., K.S., S.N., and J.J.R. performed the PACT experiments. K.B.J. performed the MRI experiments. K.S., Y.Z., S.N., C.Y.L., D.J.W. and L.V.W. analyzed and interpreted the data. J.J.R. and C.Y.L. recruited the participants. Y.Z., S.N., K.S., and J.J.R. wrote the manuscript with input from all authors. L.V.W. revised the manuscript. L.V.W., C.Y.L. and D.J.W. supervised the study. Data availability. The data that support the findings of this study are provided within the paper and its supplementary material. Code availability. The reconstruction algorithm and data processing methods can be found in Methods. The reconstruction code is not publicly available because it is proprietary and is used in licensed technologies. Competing interests. L.V.W. has a financial interest in Microphotoacoustics Inc., CalPACT LLC, and Union Photoacoustic Technologies Ltd., which, however, did not support this work.
Funding AgencyGrant Number
NIHU01 NS099717
NIHR01 NS102213
NIHR35 CA220436
Record Number:CaltechAUTHORS:20220707-204134339
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:115414
Deposited By: George Porter
Deposited On:08 Jul 2022 22:25
Last Modified:08 Jul 2022 22:25

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