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LEUNIG regulates AGAMOUS expression in Arabidopsis flowers

Liu, Zhongchi and Meyerowitz, Elliot M. (1995) LEUNIG regulates AGAMOUS expression in Arabidopsis flowers. Development, 121 (4). pp. 975-991. ISSN 0950-1991.

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LEUNIG was identified in a genetic screen designed to isolate second-site enhancer mutations of the floral homeotic mutant apetala2-1. leunig mutations not only enhance apetala2, but by themselves cause a similar but less-pronounced homeotic transformation than apetala2 mutations. leunig flowers have sepals that are transformed toward stamens and carpels, and petals that are either staminoid or absent. In situ hybridization experiments with leunig mutants revealed altered expression pattern of the floral homeotic genes APETALA1, APETALA3, PISTILLATA, and AGAMOUS. Double mutants of leunig and agamous exhibited a phenotype similar to agamous single mutants, indicating that agamous is epistatic to leunig. Our analysis suggests that a key role of LEUNIG is to negatively regulate AGAMOUS expression in the first two whorls of the Arabidopsis flower.

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Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1995 by Company of Biologists. (Accepted 9 January 1995) We thank Susan Apostolaki for help with the genetic screen and David Smyth for initially pointing out the resemblance of our enhancer mutants to leunig and F1-89. We thank George Fox, Tom Jack, Steven Jacobsen, Joshua Levin, Kiyotaka Okada, David Smyth, and Detlef Weigel for giving us lug alleles. We also thank John Bowman, Caren Chang, Steven E. Clark, Justin Goodrich, Tom Jack, Steve Jacobsen, Beth Krizek, Joshua Levin, Jose Luis Riechmann, Mark Running, Hajime Sakai, Leslie Sieburth, David Smyth, Detlef Weigel, and Liz Zimmer for discussion, suggestions and comments on the manuscript. Z.L. is a DOE-energy Biosciences Research Fellow of the Life Science Research Foundation, and also previously a Damon Runyon-Walter Winchell Cancer Research Fund postdoctoral fellow. This work was supported by NIH grant GM 45697 to E.M.M.
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Department of Energy (DOE)UNSPECIFIED
Life Sciences Research FoundationUNSPECIFIED
Damon Runyan-Walter Winchell Cancer Research FundUNSPECIFIED
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Official Citation:LEUNIG regulates AGAMOUS expression in Arabidopsis flowers Z. Liu, E.M. Meyerowitz Development 1995 121: 975-991
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11543
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Deposited On:03 Sep 2008 23:21
Last Modified:03 Oct 2019 00:20

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