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Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson’s Disease

Williams, Gregory P. and Schonhoff, Aubrey M. and Sette, Alessandro and Lindestam Arlehamn, Cecilia S. (2022) Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson’s Disease. Journal of Parkinson's Disease . ISSN 1877-7171. doi:10.3233/jpd-223241. (In Press)

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Inflammation has increasingly become a focus of study in regards to Parkinson’s disease (PD). Moreover, both central and peripheral sources of inflammation have been implicated in the pathogenesis of PD. Central inflammation consisting of activated microglia, astroglia, and T cell responses within the PD central nervous system; and peripheral inflammation referring to activated innate cells and T cell signaling in the enteric nervous system, gastrointestinal tract, and blood. This review will highlight important work that further implicates central and peripheral inflammation in playing a role in PD. We also discuss how these two distant inflammations appear related and how that may be mediated by autoantigenic responses to α-syn.

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Schonhoff, Aubrey M.0000-0002-1801-1125
Additional Information:© 2021 – The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0). Accepted 30 May 2022 | Published: 23 June 2022. This study was supported by the joint efforts of The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and the Aligning Science Across Parkinson’s (ASAP) initiative as well as the NIH T32AI125179 (GPW). MJFF administers the grant ASAP-000375 on behalf of the ASAP and itself. The authors have no conflicts of interest to report.
Funding AgencyGrant Number
Michael J. Fox FoundationUNSPECIFIED
Aligning Science Across Parkinson’sASAP-000375
NIH Predoctoral FellowshipT32AI125179
Subject Keywords:Neuroimmunology, neuroinflammation, Parkinson’s disease, T cells, central inflammation, peripheral inflammation
Record Number:CaltechAUTHORS:20220712-629606000
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:115507
Deposited By: George Porter
Deposited On:13 Jul 2022 21:32
Last Modified:13 Jul 2022 21:32

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