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Alpha desynchronization during Stroop test unmasks cognitively healthy individuals with abnormal CSF Amyloid/Tau

Arakaki, Xianghong and Hung, Shao-Min and Rochart, Roger and Fonteh, Alfred N. and Harrington, Michael G. (2022) Alpha desynchronization during Stroop test unmasks cognitively healthy individuals with abnormal CSF Amyloid/Tau. Neurobiology of Aging, 112 . pp. 87-101. ISSN 0197-4580. PMCID PMC8976735. doi:10.1016/j.neurobiolaging.2021.11.009. https://resolver.caltech.edu/CaltechAUTHORS:20220712-629954000

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Abstract

Synaptic dysfunctions precede cognitive decline in Alzheimer's disease by decades, affect executive functions, and can be detected by quantitative electroencephalography (qEEG). We used quantitative electroencephalography combined with Stroop testing to identify changes of inhibitory controls in cognitively healthy individuals with an abnormal versus normal ratio of cerebrospinal fluid (CSF) amyloid/total-tau. We studied two groups of participants (60–94 years) with either normal (CH-NAT or controls, n = 20) or abnormal (CH-PAT, n = 21) CSF amyloid/tau ratio. We compared: alpha event-related desynchronization (ERD), alpha spectral entropy (SE), and their relationships with estimated cognitive reserve. CH-PATs had more negative occipital alpha ERD, and higher frontal and occipital alpha SE during low load congruent trials, indicating hyperactivity. CH-PATs demonstrated fewer frontal SE changes with higher load, incongruent Stroop testing. Correlations of alpha ERD with estimated cognitive reserve were significant in CH-PATs but not in CH-NATs. These results suggested compensatory hyperactivity in CH-PATs compared to CH-NATs. We did not find differences in alpha ERD comparisons with individual CSF amyloid(A), p-tau(T), total-tau(N) biomarkers.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.neurobiolaging.2021.11.009DOIArticle
ORCID:
AuthorORCID
Arakaki, Xianghong0000-0003-0721-7168
Hung, Shao-Min0000-0002-8908-1497
Fonteh, Alfred N.0000-0003-4860-5749
Harrington, Michael G.0000-0002-7923-8032
Additional Information:© 2021 Elsevier. Received 21 July 2020, Revised 27 November 2021, Accepted 30 November 2021, Available online 5 December 2021, Version of Record 20 January 2022. We thank the study participants for their contributions. Betty Chung and David Buennagel assisted with participant recruitment. Dr. Anne Nolty and faculty-supervised graduate students of Fuller psychology department performed psychometry testing. Dr. Helena Chui and Dr. Kloner helped with clinical conference for participant classification. Dr. Kloner, Dr. Kleinman, and Dr. Rebecca J Arechavala edited the manuscript. Dr. Quanying Liu helped with the estimated Innotest amyloid and tau conversions. Some data relied upon in this study was derived from research performed at HMRI by Dr. Michael G. Harrington. This work was supported by the National Institutes of Aging [grant number R56AG063857, R01AG063857] and L. K. Whittier Foundation. Author contributions. Conception and design of the study: XA MGH. Acquisition of the data: XA MGH. Analysis of the data: XA SMH RR AF MGH. Wrote the paper, XA. Edited the paper: XA SMH RR AF MGH. All authors contributed toward discussions of the results and the final manuscript. Credit author statement. Conception and design of the study: XA MGH. Acquisition of the data: XA MGH. Analysis of the data: XA SMH RR AF MGH. Wrote the paper, XA. Edited the paper: XA SMH RR AF MGH. All authors contributed toward the final manuscript. Submission declaration and verification. For the manuscript “Alpha desynchronization during Stroop test unmask cognitively healthy individuals with abnormal CSF Amyloid/Tau”: this work has not been published previously (except in the form of an abstract, a published lecture), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, including electronically without the written consent of the copyright-holder. The authors have no actual or potential conflicts of interest.
Funders:
Funding AgencyGrant Number
NIHR56AG063857
NIHR01AG063857
L. K. Whittier FoundationUNSPECIFIED
Subject Keywords:CH-PATs; CH-NATs; electroencephalography; Stroop; alpha event-related desynchronization; spectral entropy
PubMed Central ID:PMC8976735
DOI:10.1016/j.neurobiolaging.2021.11.009
Record Number:CaltechAUTHORS:20220712-629954000
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220712-629954000
Official Citation:Xianghong Arakaki, Shao-Min Hung, Roger Rochart, Alfred N. Fonteh, Michael G. Harrington, Alpha desynchronization during Stroop test unmasks cognitively healthy individuals with abnormal CSF Amyloid/Tau, Neurobiology of Aging, Volume 112, 2022, Pages 87-101, ISSN 0197-4580, https://doi.org/10.1016/j.neurobiolaging.2021.11.009.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:115520
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:13 Jul 2022 19:46
Last Modified:13 Jul 2022 19:46

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