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High rates of blood transfusion associated with Parkinson’s disease

Shahrestani, Shane and Gendreau, Julian and Tafreshi, Ali R. and Brown, Nolan J. and Dashtipour, Khashayar (2022) High rates of blood transfusion associated with Parkinson’s disease. Neurological Sciences, 43 (8). pp. 4761-4768. ISSN 1590-1874. PMCID PMC9349070. doi:10.1007/s10072-022-06097-6. https://resolver.caltech.edu/CaltechAUTHORS:20220713-792560100

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Abstract

Background: As evidence continues to accumulate regarding the multi-organ dysfunction associated with Parkinson’s disease (PD), it is still unclear as to whether PD increases the risk of hematological pathology. In this study, the authors investigate the association between PD and hematological pathology risk factors. Methods: This retrospective cohort analysis was conducted using 8 years of the National Readmission Database. All individuals diagnosed with PD were queried at the time of primary admission. Readmissions, complications, and risk factors were analyzed at 30-, 90-, 180-, and 300-day intervals. Statistical analysis included multivariate Gaussian-fitted modeling using age, sex, comorbidities, and discharge weights as covariates. Coefficients of model variables were exponentiated and interpreted as odds ratios. Results: The database query yielded 1,765,800 PD patients (mean age: 76.3 ± 10.4; 44.1% female). Rates of percutaneous blood transfusion in readmitted patients at 30, 90, 180, and 300 days were found to be 8.7%, 8.6%, 8.3%, and 8.3% respectively. Those with anti-parkinsonism medication side effects at the primary admission had increased rates of gastrointestinal (GI) hemorrhage (OR: 1.02; 95%CI: 1.01–1.03, p < 0.0001) and blood transfusion (OR: 1.06; 95%CI: 1.05–1.08, p < 0.0001) at all timepoints after readmission. PD patients who experienced GI hemorrhage of any etiology, including as a side effect of anti-parkinsonism medication, were found to have significantly higher rates of blood transfusion at all timepoints (OR: 1.14; 95%CI: 1.13–1.16, p < 0.0001). Conclusions: Blood transfusions were found to be significantly associated with anti-parkinsonism drug side effects and GI hemorrhage of any etiology.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/s10072-022-06097-6DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9349070/PubMed CentralArticle
ORCID:
AuthorORCID
Shahrestani, Shane0000-0001-7561-4590
Gendreau, Julian0000-0001-8412-0437
Tafreshi, Ali R.0000-0002-8956-3373
Brown, Nolan J.0000-0002-6025-346X
Dashtipour, Khashayar0000-0003-3547-0443
Additional Information:© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Received 04 November 2021; Accepted 03 April 2022; Published 02 May 2022. Ethical approval and Informed consent: This study did not involve research with human subjects, so ethical approval and informed consent were not required. The authors declare no competing interests.
Subject Keywords:Parkinson’s disease; Hematology; Blood Transfusion; Gastrointestinal bleeding
Issue or Number:8
PubMed Central ID:PMC9349070
DOI:10.1007/s10072-022-06097-6
Record Number:CaltechAUTHORS:20220713-792560100
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220713-792560100
Official Citation:Shahrestani, S., Gendreau, J., Tafreshi, A.R. et al. High rates of blood transfusion associated with Parkinson’s disease. Neurol Sci 43, 4761–4768 (2022). https://doi.org/10.1007/s10072-022-06097-6
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:115526
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Jul 2022 16:02
Last Modified:15 Aug 2022 22:30

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