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Discovery of cellular regulation by protein degradation

Varshavsky, Alexander (2008) Discovery of cellular regulation by protein degradation. Journal of Biological Chemistry, 283 (50). pp. 34469-34489. ISSN 0021-9258. PMCID PMC3259866. https://resolver.caltech.edu/CaltechAUTHORS:VARjbc08

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Abstract

What follows is a story of some of the lab’s adventures mentioned above, including the inventions of new biochemical and genetic methods. This account stems, in part, from previous descriptions of the early history of the Ub field (31,32). Another antecedent is an interview I gave to Dr. Istvan Hargittai, a distinguished Hungarian chemist. It describes my life and science, including the early years in Moscow, the 1977 escape from the former Soviet Union, the essentially accidental hiring of me by MIT, and the work that ensued (33). The narrative below borrows from these sources, and mentions our more recent contributions as well.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1074/jbc.X800009200DOIArticle
http://www.jbc.org/cgi/content/abstract/283/43/34469PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259866/PubMed CentralArticle
ORCID:
AuthorORCID
Varshavsky, Alexander0000-0002-4011-258X
Additional Information:© 2008 the American Society for Biochemistry and Molecular Biology. Submitted on August 6, 2008. Accepted on August 15, 2008. Originally published In Press as doi:10.1074/jbc.X800009200 on August 15, 2008. Papers In Press, published online ahead of print August 18, 2008. Our studies are supported by the NIH, and by private foundations as well. I am most grateful to the past and present colleagues in my laboratory for their contributions, many of which are mentioned above. I also thank C. Brower, W. Dunphy, R. Deshaies, A. Shemorry, O. Sundin and W. Tansey for helpful comments on the paper.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Subject Keywords:proteolysis; N-end rule; chromosome; segregation; decatenation
Issue or Number:50
PubMed Central ID:PMC3259866
Record Number:CaltechAUTHORS:VARjbc08
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:VARjbc08
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11570
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:05 Sep 2008 21:05
Last Modified:03 Oct 2019 00:20

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