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Symbiosis-driven development in an early branching metazoan

Ohdera, Aki H. and Darymple, Justin and Avila-Magaña, Viridiana and Sharp, Victoria and Watson, Kelly and McCauley, Mark and Steinworth, Bailey and Diaz-Almeyda, Erika M. and Kitchen, Sheila A. and Poole, Angela Z. and Bellantuono, Anthony and Haridas, Sajeet and Grigoriev, Igor V. and Goentoro, Lea and Vallen, Elizabeth and Baker, David M. and LaJeunesse, Todd C. and Loesgen, Sandra and Martindale, Mark Q. and DeGennaro, Matthew and Fitt, William K. and Medina, Mónica (2022) Symbiosis-driven development in an early branching metazoan. . (Unpublished)

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Microbes can initiate developmental gene regulatory cascades in animals. The molecular mechanisms underlying microbe-induced animal development and the evolutionary steps to integrate microbial signals into regulatory programs remain poorly understood. In the upside-down jellyfish Cassiopea xamachana, a dinoflagellate endosymbiont initiates the life stage transition from the sessile polyp to the sexual medusa. We found that metabolic products derived from symbiont carotenoids may be important to initiate C. xamachana development, in addition to expression of conserved genes involved in medusa development of non-symbiotic jellyfish. We also revealed the transcription factor COUP is expressed during metamorphosis, potentially as a co-regulator of nuclear receptor RXR. These data suggest relatively few steps may be necessary to integrate symbiont signals into gene regulatory networks and cements the role of the symbiont as a key trigger for life history transition in C. xamachana.

Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription Paper Information
Ohdera, Aki H.0000-0003-4417-905X
Avila-Magaña, Viridiana0000-0001-6249-4761
McCauley, Mark0000-0001-5347-6860
Diaz-Almeyda, Erika M.0000-0003-4923-0627
Kitchen, Sheila A.0000-0003-4402-8139
Bellantuono, Anthony0000-0003-1090-564X
Haridas, Sajeet0000-0002-0229-0975
Grigoriev, Igor V.0000-0002-3136-8903
Goentoro, Lea0000-0002-3904-0195
Baker, David M.0000-0002-0308-4954
LaJeunesse, Todd C.0000-0001-7607-9358
Loesgen, Sandra0000-0003-1090-564X
Martindale, Mark Q.0000-0002-5805-5640
DeGennaro, Matthew0000-0003-3837-4430
Fitt, William K.0000-0002-8619-1244
Medina, Mónica0000-0001-8367-0293
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. The work conducted by the U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility, is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The authors have declared no competing interest.
Funding AgencyGrant Number
Department of Energy (DOE)DE-AC02-05CH11231
Record Number:CaltechAUTHORS:20220725-414384000
Persistent URL:
Official Citation:Symbiosis-driven development in an early branching metazoan Aki H. Ohdera, Justin Darymple, Viridiana Avila-Magaña, Victoria Sharp, Kelly Watson, Mark McCauley, Bailey Steinworth, Erika M. Diaz-Almeyda, Sheila A. Kitchen, Angela Z. Poole, Anthony Bellantuono, Sajeet Haridas, Igor V. Grigoriev, Lea Goentoro, Elizabeth Vallen, David M. Baker, Todd C. LaJeunesse, Sandra Loesgen, Mark Q. Martindale, Matthew DeGennaro, William K. Fitt, Mónica Medina bioRxiv 2022.07.21.500558; doi:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:115809
Deposited By: George Porter
Deposited On:27 Jul 2022 15:51
Last Modified:27 Jul 2022 15:51

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