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Looking on the Horizon; Potential and Unique Approaches to Developing Radiation Countermeasures for Deep Space Travel

Bokhari, Rihana S. and Beheshti, Afshin and Blutt, Sarah E. and Bowles, Dawn E. and Brenner, David and Britton, Robert and Bronk, Lawrence and Cao, Xu and Chatterjee, Anushree and Clay, Delisa E. and Courtney, Colleen and Fox, Donald T. and Gaber, M. Waleed and Gerecht, Sharon and Grabham, Peter and Grosshans, David and Guan, Fada and Jezuit, Erin A. and Kirsch, David G. and Liu, Zhandong and Maletic-Savatic, Mirjana and Miller, Kyle M. and Montague, Ruth A. and Nagpal, Prashant and Osenberg, Sivan and Parkitny, Luke and Pierce, Niles A. and Porada, Christopher and Rosenberg, Susan M. and Sargunas, Paul and Sharma, Sadhana and Spangler, Jamie and Tavakol, Daniel Naveed and Thomas, Dilip and Vunjak-Novakovic, Gordana and Wang, Chunbo and Whitcomb, Luke and Young, Damian W. and Donoviel, Dorit (2022) Looking on the Horizon; Potential and Unique Approaches to Developing Radiation Countermeasures for Deep Space Travel. Life Sciences in Space Research . ISSN 2214-5524. doi:10.1016/j.lssr.2022.08.003. (In Press)

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Future lunar missions and beyond will require new and innovative approaches to radiation countermeasures. The Translational Research Institute for Space Health (TRISH) is focused on identifying and supporting unique approaches to reduce risks to human health and performance on future missions beyond low Earth orbit. This paper will describe three funded and complementary avenues for reducing the risk to humans from radiation exposure experienced in deep space. The first focus is on identifying new therapeutic targets to reduce the damaging effects of radiation by focusing on high throughput genetic screens in accessible, sometimes called lower, organism models. The second focus is to design innovative approaches for countermeasure development with special attention to nucleotide-based methodologies that may constitute a more agile way to design therapeutics. The final focus is to develop new and innovative ways to test radiation countermeasures in a human model system. While animal studies continue to be beneficial in the study of space radiation, they can have imperfect translation to humans. The use of three-dimensional (3D) complex in vitro models is a promising approach to aid the development of new countermeasures and personalized assessments of radiation risks. These three distinct and unique approaches complement traditional space radiation efforts and should provide future space explorers with more options to safeguard their short and long-term health.

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Pierce, Niles A.0000-0003-2367-4406
Additional Information:© 2022 Published by Elsevier B.V. on behalf of The Committee on Space Research (COSPAR). Under an Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). Received 8 March 2022, Revised 29 July 2022, Accepted 4 August 2022, Available online 7 August 2022. This work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A. Conflict of Interest: None.
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Subject Keywords:Space Radiation; 3D tissue; Organoid; Extremophile; Nucleotide-based Approaches; Radiation Countermeasure
Record Number:CaltechAUTHORS:20220808-223919000
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Official Citation:Rihana S. Bokhari, Afshin Beheshti, Sarah E. Blutt, Dawn E. Bowles, David Brenner, Robert Britton, Lawrence Bronk, Xu Cao, Anushree Chatterjee, Delisa E. Clay, Colleen Courtney, Donald T. Fox, M. Waleed Gaber, Sharon Gerecht, Peter Grabham, David Grosshans, Fada Guan, Erin A. Jezuit, David G. Kirsch, Zhandong Liu, Mirjana Maletic-Savatic, Kyle M. Miller, Ruth A. Montague, Prashant Nagpal, Sivan Osenberg, Luke Parkitny, Niles A. Pierce, Christopher Porada, Susan M. Rosenberg, Paul Sargunas, Sadhana Sharma, Jamie Spangler, Daniel Naveed Tavakol, Dilip Thomas, Gordana Vunjak-Novakovic, Chunbo Wang, Luke Whitcomb, Damian W. Young, Dorit Donoviel, Looking on the Horizon; Potential and Unique Approaches to Developing Radiation Countermeasures for Deep Space Travel, Life Sciences in Space Research, 2022, , ISSN 2214-5524,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:116165
Deposited By: George Porter
Deposited On:09 Aug 2022 14:33
Last Modified:09 Aug 2022 14:33

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