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Premotor population dynamics as neural substrate for auditory and visual rhythmic entrainment

Betancourt, Abraham and Pérez, Oswaldo and Gámez, Jorge and Mendoza, Germán and Merchant, Hugo (2022) Premotor population dynamics as neural substrate for auditory and visual rhythmic entrainment. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20220815-504458000

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Abstract

Precise timing is a fundamental requisite for a select group of complex actions, such as music appreciation and performance, where subjects extract the regular beat of a rhythmic sequence to generate an internal pulse representation that allows for predictive responses to the beat. The neural substrate for beat extraction and response entrainment to auditory and visual rhythms is still largely unknown. Here we recorded and analyzed the population activity of hundreds of MPC neurons of two rhesus monkeys performing an isochronous tapping task guided by brief flashing stimuli or auditory tones. The animals showed a strong bias towards visual metronomes, with rhythmic tapping that was more precise and accurate than for auditory metronomes. The population dynamics in state space as well as the corresponding neural sequences shared the following properties across modalities: the circular dynamics of the neural trajectories and the neural sequences formed a regenerating loop for every produced interval, producing a relative time representation; the trajectories converged in similar state space at tapping times while the moving bumps restart at this point, resetting the beat-based clock; the tempo of the synchronized tapping was encoded by a combination of amplitude modulation and temporal scaling in the neural trajectories. The latter correlated with a mixture of response duration and recruitment properties in the neural sequences. In addition, the modality induced a displacement in the neural trajectories in auditory and visual subspaces without greatly altering time keeping mechanism. These results suggest that the interaction between the amodal internal representation of pulse within MPC and a modality specific external input generates a neural rhythmic clock whose dynamics define the temporal execution of tapping using auditory and visual metronomes.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/2022.08.14.503904DOIArticle
https://www.biorxiv.org/content/10.1101/2022.08.14.503904v1.supplementary-materialPublisherSupporting Information
ORCID:
AuthorORCID
Betancourt, Abraham0000-0001-8840-527X
Pérez, Oswaldo0000-0002-1888-7434
Gámez, Jorge0000-0002-9481-4915
Mendoza, Germán0000-0001-9856-5349
Merchant, Hugo0000-0002-3488-9501
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license. Abraham Azahel Betancourt Vera is a doctoral student from the Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM) and has received CONACYT fellowship 403878. Hugo Merchant is supported by CONACYT: 236836, CONACYT: 196, and PAPIIT: IN202317. We thank Raul Paulín and Luis Prado for their technical assistance. Author contributions. A.B. and H.M. conceived the study. A.B. and J.G. collected the data. A.B., O.P. and H.M. performed data analyses. O.P. and G.M. contributed analytical tools and guidance. H.M. supervised the project. A.B. and H.M. wrote the manuscript. A.B., J.G., G.M., O.P and H.M. edited the manuscript. Data availability. The data used to generate the associated figures will be made available upon request. Code availability. The code used to generate the associated figures will be made available upon request. The authors have declared no competing interest.
Funders:
Funding AgencyGrant Number
Consejo Nacional de Ciencia y Tecnología (CONACYT)403878
Consejo Nacional de Ciencia y Tecnología (CONACYT)236836
Consejo Nacional de Ciencia y Tecnología (CONACYT)196
Universidad Nacional Autónoma de México (UNAM)IN202317
DOI:10.1101/2022.08.14.503904
Record Number:CaltechAUTHORS:20220815-504458000
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220815-504458000
Official Citation:Premotor population dynamics as neural substrate for auditory and visual rhythmic entrainment Abraham Betancourt, Oswaldo Pérez, Jorge Gámez, Germán Mendoza, Hugo Merchant bioRxiv 2022.08.14.503904; doi: https://doi.org/10.1101/2022.08.14.503904
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:116282
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:16 Aug 2022 14:43
Last Modified:16 Aug 2022 14:43

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