CaltechAUTHORS
  A Caltech Library Service

Pollen Typhae-Based Magnetic-Powered Microrobots toward Acute Gastric Bleeding Treatment

Yang, Qingxin and Tang, Songsong and Lu, Dongdong and Li, Yangyang and Wan, Fangchen and Li, Jiahong and Chen, Qiwei and Cong, Zhaoqing and Zhang, Xueji and Wu, Song (2022) Pollen Typhae-Based Magnetic-Powered Microrobots toward Acute Gastric Bleeding Treatment. ACS Applied Bio Materials, 5 (9). ISSN 2576-6422. doi:10.1021/acsabm.2c00565. https://resolver.caltech.edu/CaltechAUTHORS:20220816-201464000

[img] PDF - Supplemental Material
See Usage Policy.

1MB
[img] Video (QuickTime) (Propulsion performance of PT robots upon RMF control with different intensities (Movie S1)) - Supplemental Material
See Usage Policy.

1MB
[img] Video (QuickTime) (Propulsion performance of PT robots upon RMF control with different frequencies (Movie S2)) - Supplemental Material
See Usage Policy.

2MB
[img] Video (QuickTime) (Propulsion performance of PT robots in various biological media upon RMF control (Movie S3)) - Supplemental Material
See Usage Policy.

3MB
[img] Video (QuickTime) (Motion trajectory of the PT robot in a predefined rectangle-like path (Movie S4)) - Supplemental Material
See Usage Policy.

17MB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20220816-201464000

Abstract

Traditional Chinese herbal medicine (TCHM) is the naturally available pharmaceutical with millennia of evolution from ancient China, capable of a superior therapeutic index and minimized unwanted effects on the human body. This work presents a therapeutic microrobotic platform based on pollen typhae (PT), a typical type of TCHM, fabricated by coating porous PT microspheres with Fe₃O₄ nanoparticles (PT robots) via electrostatic adsorption. The PT robots exhibit effective and controllable motion in various biological media upon external magnetic control and, meanwhile, preserve the inherent hemostasis property of PT. The blood clotting capacity of PT robots is attributed to their stimulation of the endogenous blood coagulation pathway and platelets with increased counts, which could be further improved by their effective magnetic propulsion. The remote magnetic control also allows the manipulation of PT robots in mice stomach, inducing enhanced binding and prolonged retention of PT robots in stomach mucosa. Moreover, PT robots upon magnetic control show an enhanced hemostatic effect in treating the mice bearing acute gastric bleeding compared with other passive groups. This work offers a facile and feasible route to integrate TCHM with manmade micromachines possessing the innate curative features of TCHM. Such a design expanded the versatility of microrobots and can be generalized to vast types of TCHM for broader biomedical applications.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/acsabm.2c00565DOIArticle
ORCID:
AuthorORCID
Li, Jiahong0000-0001-7938-9589
Cong, Zhaoqing0000-0003-2737-7636
Zhang, Xueji0000-0002-0035-3821
Wu, Song0000-0003-3504-1630
Additional Information:© 2022 American Chemical Society. Received 21 June 2022. Accepted 2 August 2022. Published online 15 August 2022. This work was supported by the Guangdong Special Support Program of Youth Talent with Scientific and Technological Innovation, National Key Research and Development Program of China (2017YFA0105900), National Natural Science Foundation Fund of China (81922046, 61931024, and 32101133), Special Funds for Strategic Emerging Industries Development in Shenzhen (20180309163446298), Shenzhen Science and Technology Program (grant number JCYJ20210324125006019), and Shenzhen Key Laboratory Program (ZDSYS20190902092857146). The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
Guangdong Science and Technology DepartmentUNSPECIFIED
Ministry of Science and Technology of the People's Republic of China2017YFA0105900
National Natural Science Foundation of China81922046
National Natural Science Foundation of China61931024
National Natural Science Foundation of China32101133
Development and Reform Commission of Shenzhen Municipality20180309163446298
Science, Technology and Innovation Commission of Shenzhen MunicipalityJCYJ20210324125006019
Science, Technology and Innovation Commission of Shenzhen MunicipalityZDSYS20190902092857146
Subject Keywords:traditional Chinese herbal medicine; pollen typhae; microrobots; magnetic propulsion; acute gastric bleeding
Issue or Number:9
DOI:10.1021/acsabm.2c00565
Record Number:CaltechAUTHORS:20220816-201464000
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220816-201464000
Official Citation:Pollen Typhae-Based Magnetic-Powered Microrobots toward Acute Gastric Bleeding Treatment Qingxin Yang, Songsong Tang, Dongdong Lu, Yangyang Li, Fangchen Wan, Jiahong Li, Qiwei Chen, Zhaoqing Cong, Xueji Zhang, and Song Wu ACS Applied Bio Materials Article ASAP DOI: 10.1021/acsabm.2c00565
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:116300
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:16 Aug 2022 20:51
Last Modified:06 Oct 2022 23:38

Repository Staff Only: item control page