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Nitrogen metabolism of the isolated tissues of the rat

Borsook, Henry and Jeffreys, Cecil E. P. (1935) Nitrogen metabolism of the isolated tissues of the rat. Journal of Biological Chemistry, 110 (2). pp. 495-509. ISSN 0021-9258.

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Little study has been devoted to the anabolic aspects of nitrogen metabolism in animals. The reason, of course, has been the difficulty of obtaining experimental conditions in which these can be observed, measured, and analyzed. The experiments of Krebs and Henseleit (1) on the formation of urea from ammonia with Warburg’s method of surviving slices of liver suggested that this method might be useful in a direct attack on a number of problems of nitrogen anabolism in animals; i.e., it might be possible to observe reactions in which there is a gain in free energy. It appears that for these reactions the intact cell structure is necessary.

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Additional Information:© 1935 American Society of Biological Chemists. Received for publication, May 13, 1935.
Issue or Number:2
Record Number:CaltechAUTHORS:BORjbc35b
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11667
Deposited By: Tony Diaz
Deposited On:30 Sep 2008 17:33
Last Modified:03 Oct 2019 00:21

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