A Caltech Library Service

Qa-region class I gene expression: identification of a second class I gene, Q9, encoding a Qa-2 polypeptide

Soloski, Mark J. and Hood, Leroy and Stroynowski, Iwona (1988) Qa-region class I gene expression: identification of a second class I gene, Q9, encoding a Qa-2 polypeptide. Proceedings of the National Academy of Sciences of the United States of America, 85 (9). pp. 3100-3104. ISSN 0027-8424. PMCID PMC280151. doi:10.1073/pnas.85.9.3100.

PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


A feature of the expression of the tissue-specific class I antigen Qa-2 is the quantitative variation among mouse strains. Recently, the class I gene Q7 has been shown to encode a protein product that is biochemically indistinguishable from the lymphocyte-bound Qa-2 molecule. Utilizing gene transfection, we have identified a second Qa-2 subregion class I gene (Q9), in H-2b mice, which encodes a polypeptide biochemically similar to the Q7 and the Qa-2 polypeptides. Furthermore, we have observed that cell lines transfected with the allelic forms of the Q7 gene from C57BL/10 (Qa-2hi) or BALB/C (Qa-2low) display quantitative differences in cell-surface expression. Based on these studies, we suggest that gene dosage and allele-specific variation in cell-surface expression contribute to the strain-specific variation in the levels of Qa-2 antigen expression.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Hood, Leroy0000-0001-7158-3678
Additional Information:© 1988 by the National Academy of Sciences. Communicated by Kimishige Ishizaka, December 23, 1987. We thank Dr. Martin Low for his kind gift of purified phospholipase. The assistance of Mrs. Seema Thakur, Mrs. Dawn Schott, and Mrs. Andrea Lulkowski during the preparation of this manuscript is gratefully acknowledged. We are indebted to the technical assistance of Alan Lattimore and K. Blackburn. This work was supported by National Institutes of Health Grant AI 20922 and American Cancer Society Grant I-378 to M.S. and National Institutes of Health Grant AI 19624 to L.H. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funding AgencyGrant Number
NIHAI 20922
American Cancer SocietyI-378
NIHAI 19624
Issue or Number:9
PubMed Central ID:PMC280151
Record Number:CaltechAUTHORS:SOLpnas88
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11674
Deposited By: Archive Administrator
Deposited On:18 Sep 2008 05:20
Last Modified:08 Nov 2021 22:01

Repository Staff Only: item control page