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Optical imaging and spectroscopy for the study of the human brain: status report

Ayaz, Hasan and Baker, Wesley B. and Blaney, Giles and Boas, David A. and Bortfeld, Heather and Brady, Kenneth and Brake, Joshua and Brigadoi, Sabrina and Buckley, Erin M. and Carp, Stefan A. and Cooper, Robert J. and Cowdrick, Kyle R. and Culver, Joseph P. and Dan, Ippeita and Dehghani, Hamid and Devor, Anna and Durduran, Turgut and Eggebrecht, Adam T. and Emberson, Lauren L. and Fang, Qianqian and Fantini, Sergio and Franceschini, Maria Angela and Fischer, Jonas B. and Gervain, Judit and Hirsch, Joy and Hong, Keum-Shik and Horstmeyer, Roarke and Kainerstorfer, Jana M. and Ko, Tiffany S. and Licht, Daniel J. and Liebert, Adam and Luke, Robert and Lynch, Jennifer M. and Mesquida, Jaume and Mesquita, Rickson C. and Naseer, Noman and Novi, Sergio L. and Orihuela-Espina, Felipe and O’Sullivan, Thomas D. and Peterka, Darcy S. and Pifferi, Antonio and Pollonini, Luca and Sassaroli, Angelo and Sato, João Ricardo and Scholkmann, Felix and Spinelli, Lorenzo and Srinivasan, Vivek J. and St. Lawrence, Keith and Tachtsidis, Ilias and Tong, Yunjie and Torricelli, Alessandro and Urner, Tara and Wabnitz, Heidrun and Wolf, Martin and Wolf, Ursula and Xu, Shiqi and Yang, Changhuei and Yodh, Arjun G. and Yücel, Meryem A. and Zhou, Wenjun (2022) Optical imaging and spectroscopy for the study of the human brain: status report. Neurophotonics, 9 (S2). Art. No. S24001. ISSN 2329-423X. PMCID PMC9424749. doi:10.1117/1.nph.9.s2.s24001.

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This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit of novel methods to explore brain health and function. While the first report focused on neurophotonic tools mostly applicable to animal studies, here, we highlight optical spectroscopy and imaging methods relevant to noninvasive human brain studies. We outline current state-of-the-art technologies and software advances, explore the most recent impact of these technologies on neuroscience and clinical applications, identify the areas where innovation is needed, and provide an outlook for the future directions.

Item Type:Article
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URLURL TypeDescription CentralArticle
Ayaz, Hasan0000-0001-5514-2741
Blaney, Giles0000-0003-3419-4547
Boas, David A.0000-0002-6709-7711
Brake, Joshua0000-0002-5113-6886
Brigadoi, Sabrina0000-0003-3032-7381
Cooper, Robert J.0000-0001-6696-8020
Cowdrick, Kyle R.0000-0003-2236-6137
Eggebrecht, Adam T.0000-0002-6320-2676
Fang, Qianqian0000-0003-0805-935X
Franceschini, Maria Angela0000-0001-6758-423X
Gervain, Judit0000-0002-2125-6369
Hirsch, Joy0000-0002-1418-6489
Ko, Tiffany S.0000-0002-5113-0310
Luke, Robert0000-0002-4930-8351
O’Sullivan, Thomas D.0000-0001-8662-5121
Scholkmann, Felix0000-0002-1748-4852
Tachtsidis, Ilias0000-0002-8125-0313
Tong, Yunjie0000-0001-6052-8913
Torricelli, Alessandro0000-0002-6878-8936
Wabnitz, Heidrun0000-0002-3846-8659
Yang, Changhuei0000-0001-8791-0354
Yodh, Arjun G.0000-0003-4744-2706
Yücel, Meryem A.0000-0002-4291-2847
Zhou, Wenjun0000-0002-6000-253X
Additional Information:This report was edited by Erin Buckley and Rickson Mesquita. Cover design by Tara Urner. H.A. is supported by the United States Air Force Office of Scientific Research (FA9550-18-1-0455), United States Army, the National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1R21HD100997-01), NIH National Institute on Drug Abuse (NIDA) (1UG3DA050325-01), NIH National Institute of Nursing Research (NINR) (1R01NR018425-01A1), the National Science Foundation (NSF) (OAC1919691), and the Pennsylvania Dept. of Health (SAP4100083087). H.B. is supported by the NIH NIDCD (1R01DC018701) and the Carlston Cunningham Family endowment to the University of California, Merced. W.B.B. is supported by the NIH, grant R01-NS113945. S.B. is supported by grant GR-2019-12368539 from the Italian Ministry of Health. E.M.B is supported by NIH grants R01HL152322 and R01NS115994, as well as industry-sponsored support from Global Blood Therapeutics. S.A.C. is supported by NIH grants R01NS100750 and R21NS116571. R.J.C. is supported by EPSRC Fellowship EP/N025946/1. T.D. and J.B.F. are supported by Agencia Estatal de Investigación (PHOTOMETABO, PID2019106481RBC31/10.13039/501100011033) and Fundació La Marató de TV3 (201724.31, 201709.31). A.T.E. is supported by NIH National Institute of Mental Health (NIMH) “BRAINS” R01MH122751. L.L.E. is supported by the James S. McDonnell Foundation (grant 2017/AWD1005451), the Bill and Melinda Gates Foundation (grant 2020/INV-005792), and the Canadian Foundation for Innovation (grant 2021/41724). Q.F. is supported by NIH grants R01-GM114365, U24-NS124027, and R01-EB026998. S.F. is supported by NIH grants R01-NS095334 and R01-EB029414. J.G. is supported by the ERC Consolidator Grant 773202 “BabyRhythm.” K.S.H. is supported by the National Research Foundation of Korea under the Ministry of Science and ICT, Korea (2020R1A2B5B03096000). J.H. is supported by NIH grants R01MH111629, R01MH119430, and R01MH107513. J.M.K. acknowledges the financial support from the Center for Machine Learning and Health (CMLH), the American Heart Association (AHA) 17SDG33700047, and the NIH R21-EB024675. K.St.L. acknowledges the financial support of the Canadian Institutes of Health Research (CGP-130391 and 14171) and National Science and Engineering Research Council (CHRP 478470). R.C.M. is supported by the São Paulo Research Foundation (FAPESP 2013/07559-3) and the National Council for Scientific and Technological Development (CNPq Proc. 311768/2019-9). N.N. is supported by the Higher Education Commission of Pakistan through the National Centre of Robotics and Automation (NCRA) grant number NCRA-RF-027. S.L.N. is supported by São Paulo Research Foundation grants 2016/22990-0 and 2019/21962-1. T.D.O. acknowledges support from the NIH (R01EB029595). D.S.P. is supported by NIH grants U19NS104649 and U01NS113273. L.P. is supported by NSF awards CNS1650536 and TIP1919269. J.R.S. is supported by the São Paulo Research Foundation (FAPESP) through grants 2018/21934-5, 2018/04654-9, and 2021/05332-8. V.J.S. is supported by the NIH (EB029747, EY031469, NS094681, EB032840). I.T. acknowledges funding by MRC UK MR/S003134/1. A.G.Y. acknowledges support from the NIH through P41EB015893. W.Z. acknowledges support from the National Natural Science Foundation of China (62105315).
Funding AgencyGrant Number
Air Force Office of Scientific Research (AFOSR)FA9550-18-1-0455
Pennsylvania Department of HealthSAP4100083087
University of California, MercedUNSPECIFIED
Ministry of Health (Italy)GR-2019-12368539
Global Blood TherapeuticsUNSPECIFIED
Engineering and Physical Sciences Research Council (EPSRC)EP/N025946/1
Agencia Estatal de InvestigaciónPID2019106481RBC31/10.13039/501100011033
Fundació La Marató de TV3201724.31
Fundació La Marató de TV3201709.31
James S. McDonnell Foundation2017/AWD1005451
Bill and Melinda Gates Foundation2020/INV-005792
Canada Foundation for Innovation2021/41724
European Research Council (ERC)773202
Ministry of Science and ICT (Korea)2020R1A2B5B03096000
Carnegie Mellon UniversityUNSPECIFIED
American Heart Association17SDG33700047
Canadian Institutes of Health Research (CIHR)CGP-130391
Canadian Institutes of Health Research (CIHR)CGP-14171
Natural Sciences and Engineering Research Council of Canada (NSERC)CHRP 478470
Fundação de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP)2013/07559-3
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)311768/2019-9
Higher Education Commission (Pakistan)NCRA-RF-027
Fundação de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP)2016/22990-0
Fundação de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP)2019/21962-1
Fundação de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP)2018/21934-5
Fundação de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP)2018/04654-9
Fundação de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP)2021/05332-8
Medical Research Council (UK)MR/S003134/1
National Natural Science Foundation of China62105315
Issue or Number:S2
PubMed Central ID:PMC9424749
Record Number:CaltechAUTHORS:20220909-233324000
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:116891
Deposited By: Donna Wrublewski
Deposited On:08 Dec 2022 17:21
Last Modified:08 Dec 2022 17:21

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