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Modular Organization of Signal Transmission in Primate Somatosensory Cortex

Mir, Yaqub and Zalányi, László and Pálfi, Emese and Ashaber, Mária and Roe, Anna W. and Friedman, Robert M. and Négyessy, László (2022) Modular Organization of Signal Transmission in Primate Somatosensory Cortex. Frontiers in Neuroanatomy, 16 . Art. No. 915238. ISSN 1662-5129. PMCID PMC9305200. doi:10.3389/fnana.2022.915238. https://resolver.caltech.edu/CaltechAUTHORS:20220912-543195500

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Abstract

Axonal patches are known as the major sites of synaptic connections in the cerebral cortex of higher order mammals. However, the functional role of these patches is highly debated. Patches are formed by populations of nearby neurons in a topographic manner and are recognized as the termination fields of long-distance lateral connections within and between cortical areas. In addition, axons form numerous boutons that lie outside the patches, whose function is also unknown. To better understand the functional roles of these two distinct populations of boutons, we compared individual and collective morphological features of axons within and outside the patches of intra-areal, feedforward, and feedback pathways by way of tract tracing in the somatosensory cortex of New World monkeys. We found that, with the exception of tortuosity, which is an invariant property, bouton spacing and axonal convergence properties differ significantly between axons within patch and no-patch domains. Principal component analyses corroborated the clustering of axons according to patch formation without any additional effect by the type of pathway or laminar distribution. Stepwise logistic regression identified convergence and bouton density as the best predictors of patch formation. These findings support that patches are specific sites of axonal convergence that promote the synchronous activity of neuronal populations. On the other hand, no-patch domains could form a neuroanatomical substrate to diversify the responses of cortical neurons.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.3389/fnana.2022.915238DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305200PubMed CentralArticle
ORCID:
AuthorORCID
Ashaber, Mária0000-0002-5586-9585
Roe, Anna W.0000-0002-9899-5442
Friedman, Robert M.0000-0002-7391-8352
Négyessy, László0000-0002-4369-0406
Additional Information:We are grateful to Dr. Z. Somogyvári for helpful discussions and reading of the manuscript. This study was supported by NIH NS093998 and NKFIH-OTKA NN118902 as well as the Tempus Public Foundation Hungary under the Stipendium Hungaricum Scholarship.
Funders:
Funding AgencyGrant Number
NIHNS093998
Hungarian Scientific Research Fund (OTKA)NN118902
Tempus Public Foundation (Hungary)UNSPECIFIED
PubMed Central ID:PMC9305200
DOI:10.3389/fnana.2022.915238
Record Number:CaltechAUTHORS:20220912-543195500
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220912-543195500
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:116896
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Oct 2022 15:02
Last Modified:04 Oct 2022 15:02

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