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Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics

Zhang, Yide and Shen, Binglin and Wu, Tong and Zhao, Jerry and Jing, Joseph C. and Wang, Peng and Sasaki-Capela, Kanomi and Dunphy, William G. and Garrett, David and Maslov, Konstantin and Wang, Weiwei and Wang, Lihong V. (2022) Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics. Nature Communications, 13 . Art. No. 5247. ISSN 2041-1723. PMCID PMC9448739. doi:10.1038/s41467-022-33002-8. https://resolver.caltech.edu/CaltechAUTHORS:20220919-371211400

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Abstract

Many ultrafast phenomena in biology and physics are fundamental to our scientific understanding but have not yet been visualized owing to the extreme speed and sensitivity requirements in imaging modalities. Two examples are the propagation of passive current flows through myelinated axons and electromagnetic pulses through dielectrics, which are both key to information processing in living organisms and electronic devices. Here, we demonstrate differentially enhanced compressed ultrafast photography (Diff-CUP) to directly visualize propagations of passive current flows at approximately 100 m/s along internodes, i.e., continuous myelinated axons between nodes of Ranvier, from Xenopus laevis sciatic nerves and of electromagnetic pulses at approximately 5 × 10⁷ m/s through lithium niobate. The spatiotemporal dynamics of both propagation processes are consistent with the results from computational models, demonstrating that Diff-CUP can span these two extreme timescales while maintaining high phase sensitivity. With its ultrahigh speed (picosecond resolution), high sensitivity, and noninvasiveness, Diff-CUP provides a powerful tool for investigating ultrafast biological and physical phenomena.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/s41467-022-33002-8DOIArticle
https://rdcu.be/cVYObPublisherFree ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448739PubMed CentralArticle
https://www.caltech.edu/about/news/high-speed-camera-captures-signals-traveling-through-nerve-cellsFeatured InCaltech News
ORCID:
AuthorORCID
Zhang, Yide0000-0002-9463-3970
Shen, Binglin0000-0001-9687-9010
Jing, Joseph C.0000-0002-1283-3232
Wang, Peng0000-0001-8420-5326
Dunphy, William G.0000-0001-7598-8939
Garrett, David0000-0002-9747-8494
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:We thank Dr. Lei Li for discussion and assistance with preparing the animal protocol. This work was supported in part by National Institutes of Health grants R01 NS102213, U01 NS099717, R35 CA220436 (Outstanding Investigator Award), and R01 EB028277. Work in the laboratory of W.G.D. was supported by NIH R01 GM043974.
Funders:
Funding AgencyGrant Number
NIHR01 NS102213
NIHU01 NS099717
NIHR35 CA220436
NIHR01 EB028277
NIHR01 GM043974
PubMed Central ID:PMC9448739
DOI:10.1038/s41467-022-33002-8
Record Number:CaltechAUTHORS:20220919-371211400
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20220919-371211400
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:117072
Collection:CaltechAUTHORS
Deposited By: Melissa Ray
Deposited On:21 Sep 2022 18:07
Last Modified:28 Feb 2023 00:29

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