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Regulatory non-coding RNAs: everything is possible, but what is important?

Guo, Jimmy K. and Guttman, Mitchell (2022) Regulatory non-coding RNAs: everything is possible, but what is important? Nature Methods, 19 (10). pp. 1156-1159. ISSN 1548-7091. doi:10.1038/s41592-022-01629-6.

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In recent years, the number of annotated noncoding RNAs (ncRNAs) and RNA-binding proteins (RBPs) has increased dramatically. The wide range of RBPs identified highlights the enormous potential for RNA in virtually all aspects of cell biology, from transcriptional regulation to metabolic control. Yet, there is a growing gap between what is possible and what has been demonstrated to be functionally important. Here we highlight recent methodological developments in the study of RNA–protein interactions, discuss the challenges and opportunities for exploring their functional roles, and provide our perspectives on what is needed to bridge the gap in this rapidly expanding field.

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Guo, Jimmy K.0000-0002-7211-4117
Guttman, Mitchell0000-0003-4748-9352
Additional Information:The authors thank I.-M. Strazhnik for Fig. 1 and S. Hiley for editing. J.K.G. is supported by the University of Southern California MD/PhD program. Research in the Guttman laboratory is funded by the National Institutes of Health (NIH) 4DN program, an NIH Director’s Transformative R01 award, the Chan Zuckerberg Initiative and funds from California Institute of Technology.
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University of Southern CaliforniaUNSPECIFIED
Chan Zuckerberg InitiativeUNSPECIFIED
Issue or Number:10
Record Number:CaltechAUTHORS:20221019-344256700.20
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:117500
Deposited By: Research Services Depository
Deposited On:27 Oct 2022 22:03
Last Modified:28 Oct 2022 15:38

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