A Caltech Library Service

Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson's Disease

Williams, Gregory P. and Schonhoff, Aubrey M. and Sette, Alessandro and Lindestam Arlehamn, Cecilia S. (2022) Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson's Disease. Journal of Parkinson's Disease, 12 (S1). S129-S136. ISSN 1877-7171. PMCID PMC9535591. doi:10.3233/jpd-223241.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Inflammation has increasingly become a focus of study in regards to Parkinson’s disease (PD). Moreover, both central and peripheral sources of inflammation have been implicated in the pathogenesis of PD. Central inflammation consisting of activated microglia, astroglia, and T cell responses within the PD central nervous system; and peripheral inflammation referring to activated innate cells and T cell signaling in the enteric nervous system, gastrointestinal tract, and blood. This review will highlight important work that further implicates central and peripheral inflammation in playing a role in PD. We also discuss how these two distant inflammations appear related and how that may be mediated by autoantigenic responses to α-syn.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Schonhoff, Aubrey M.0000-0002-1801-1125
Additional Information:This study was supported by the joint efforts of The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and the Aligning Science Across Parkinson’s (ASAP) initiative as well as the NIH T32AI125179 (GPW). MJFF administers the grant ASAP-000375 on behalf of the ASAP and itself.
Funding AgencyGrant Number
Michael J. Fox FoundationUNSPECIFIED
Aligning Science Across Parkinson’sASAP-000375
NIH Predoctoral FellowshipT32AI125179
Issue or Number:S1
PubMed Central ID:PMC9535591
Record Number:CaltechAUTHORS:20221021-259555500.20
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:117533
Deposited By: Research Services Depository
Deposited On:28 Oct 2022 15:56
Last Modified:28 Oct 2022 15:56

Repository Staff Only: item control page