Tadayonnejad, Reza and Wilson, Andrew C. and Chu, Stephanie Anne and Corlier, Juliana and Citrenbaum, Cole and Ngo, Thuc Doan P. and Hovhannisyan, Emmily and Ginder, Nathaniel D. and Levitt, Jennifer G. and Wilke, Scott A. and Krantz, David and Bari, Ausaf A. and Leuchter, Andrew F. (2022) Use of right orbitofrontal repetitive transcranial magnetic stimulation (rTMS) augmentation for treatment-refractory obsessive-compulsive disorder with comorbid major depressive disorder. Psychiatry Research, 317 . p. 114856. ISSN 0165-1781. doi:10.1016/j.psychres.2022.114856. https://resolver.caltech.edu/CaltechAUTHORS:20221031-575177800.12
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Abstract
We examined the safety and efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) of the right orbitofrontal cortex (OFC) in patients with refractory obsessive-compulsive disorder (OCD) and comorbid Major Depressive Disorder. All participants (n = 26) received excitatory stimulation of the left dorsolateral prefrontal cortex followed by inhibitory stimulation of bilateral supplementary motor area for 10 sessions. In 18 patients with poor early OCD response, treatment was augmented with OFC inhibitory stimulation after the tenth treatment session. Augmentation with OFC stimulation was well-tolerated, and associated with further alleviation of both OCD and depression symptoms, particularly in individuals with more severe illnesses.
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| Additional Information: | RT research is supported by the National Institute of Mental Health (K23MH116117, R01MH121089) and the Brain & Behavior Research Foundation (NARSAD-27111). We thank the Ryan Family for their generous support of innovative approaches to depression treatment and groundbreaking TMS technology. | ||||||||||||||||||
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| Subject Keywords: | Comorbid OCD-MDD ; rTMS ; Orbitofrontal cortex | ||||||||||||||||||
| DOI: | 10.1016/j.psychres.2022.114856 | ||||||||||||||||||
| Record Number: | CaltechAUTHORS:20221031-575177800.12 | ||||||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20221031-575177800.12 | ||||||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||||
| ID Code: | 117653 | ||||||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||||||
| Deposited By: | Research Services Depository | ||||||||||||||||||
| Deposited On: | 09 Nov 2022 18:17 | ||||||||||||||||||
| Last Modified: | 11 Nov 2022 17:47 |
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