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The formation of glycocyamine in animal tissues

Borsook, Henry and Dubnoff, Jacob W. (1941) The formation of glycocyamine in animal tissues. Journal of Biological Chemistry, 138 (1). pp. 389-403. ISSN 0021-9258.

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It was shown in preceding communications that glycocyamine is converted into creatine by surviving liver slices (1). Our findings indicated that the methylating agent is methionine or a derivative of methionine. Liver slices can methylate glycocyamine rapidly enough to permit assignment to the liver alone, if necessary, of the task of making good the loss of creatine and creatinine in the urine. This holds for the livers of all mammals studied. We found no evidence of this methylating mechanism in any other tissues, except possibly slight activity in the kidney. In the pigeon the kidney is as effective in this respect as the liver.

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Additional Information:© 1941 American Society of Biological Chemists. Received for publication, September 18, 1940. A summary of this work has appeared (Science, 91, 551 (1940)).
Issue or Number:1
Record Number:CaltechAUTHORS:BORjbc41b
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11774
Deposited By: Tony Diaz
Deposited On:30 Sep 2008 15:38
Last Modified:03 Oct 2019 00:22

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