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Methylation of guanidoacetic acid by homocystine plus choline with rat liver slices

Borsook, Henry and Dubnoff, Jacob W. (1945) Methylation of guanidoacetic acid by homocystine plus choline with rat liver slices. Journal of Biological Chemistry, 160 (2). pp. 635-636. ISSN 0021-9258.

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The methylation of guanidoacetic acid by liver slices is accelerated by methionine; choline, under these conditions, exerts no significant accelerating effect (1). In view of the fact that homocystine plus choline can replace methionine for growth (2), and of the isotope experiments which proved the transfer in viva of the methyl groups of choline to creatine,(3) it has been suggested, from indirect evidence, that the pathway of the methyl group to creatine is more direct from methionine than from choline.(4) More specific evidence is desirable, especially as neither homocystine nor homocysteine has been identified in animal tissues.

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Additional Information:© 1945 American Society of Biological Chemists. Received for publication, August 31, 1945.
Issue or Number:2
Record Number:CaltechAUTHORS:BORjbc45
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11776
Deposited By: Tony Diaz
Deposited On:01 Oct 2008 05:39
Last Modified:03 Oct 2019 00:22

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