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Synthesis of hippuric acid in liver homogenate

Borsook, Henry and Dubnoff, Jacob W. (1947) Synthesis of hippuric acid in liver homogenate. Journal of Biological Chemistry, 168 (1). pp. 397-398. ISSN 0021-9258.

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The synthesis of hippuric acid from benaoic acid and glycine resembles in several respects the synthesis of a peptide bond. A CONH group is formed, it is a to a carboxyl group, and the free energy of its formation is of the same order of magnitude. The synthesis was demonstrated in liver and kidney slices of a number of animals; it is inhibited by 0.001 M KCN, which is in accord with the view that the necessary free energy is derived from an oxidation.(1)

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Additional Information:© 1947 American Society of Biological Chemists. Received for publication, March 8, 1947. Carried out under Contract N6-ORI-102, Task Order No. 2, United States Navy Department.
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U.S. Navy DepartmentUNSPECIFIED
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Record Number:CaltechAUTHORS:BORjbc47a
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11777
Deposited By: Tony Diaz
Deposited On:27 Sep 2008 04:01
Last Modified:03 Oct 2019 00:22

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