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Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles

Saltoun, Karin and Adolphs, Ralph and Paul, Lynn K. and Sharma, Vaibhav and Diedrichsen, Joern and Yeo, B. T. Thomas and Bzdok, Danilo (2022) Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles. Nature Human Behaviour . ISSN 2397-3374. doi:10.1038/s41562-022-01461-0. (In Press)

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Broca reported ~150 years ago that particular lesions of the left hemisphere impair speech. Since then, other brain regions have been reported to show lateralized structure and function. Yet, studies of brain asymmetry have limited their focus to pairwise comparisons between homologous regions. Here, we characterized separable whole-brain asymmetry patterns in grey and white matter structure from n = 37,441 UK Biobank participants. By pooling information on left–right shifts underlying whole-brain structure, we deconvolved signatures of brain asymmetry that are spatially distributed rather than locally constrained. Classically asymmetric regions turned out to belong to more than one asymmetry pattern. Instead of a single dominant signature, we discovered complementary asymmetry patterns that contributed similarly to whole-brain asymmetry at the population level. These asymmetry patterns were associated with unique collections of phenotypes, ranging from early lifestyle factors to demographic status to mental health indicators.

Item Type:Article
Related URLs:
URLURL TypeDescription ReadCube access
Saltoun, Karin0000-0003-0971-1266
Adolphs, Ralph0000-0002-8053-9692
Paul, Lynn K.0000-0002-3128-8313
Yeo, B. T. Thomas0000-0002-0119-3276
Bzdok, Danilo0000-0003-3466-6620
Additional Information:This study was supported by the Brain Canada Foundation, through the Canada Brain Research Fund, with the financial support of Health Canada, National Institutes of Health (grant nos. NIH R01 AG068563A and NIH R01 R01DA053301-01A1 to D.B.), the Canadian Institute of Health Research (grant nos. CIHR 438531 and CIHR 470425 to D.B.), the Healthy Brains Healthy Lives initiative (Canada First Research Excellence fund to D.B.), Google (Research Award, Teaching Award to D.B.) and by the CIFAR Artificial Intelligence Chairs programme (Canada Institute for Advanced Research to D.B.). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funding AgencyGrant Number
Brain Canada FoundationUNSPECIFIED
Canada Brain Research FundUNSPECIFIED
NIHR01 AG068563A
NIHR01 R01DA053301-01A1
Canadian Institutes of Health Research (CIHR)438531
Canadian Institutes of Health Research (CIHR)470425
Canada First Research Excellence FundUNSPECIFIED
Canadian Institute for Advanced Research (CIFAR)UNSPECIFIED
Record Number:CaltechAUTHORS:20221121-712922500.36
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:117968
Deposited By: Research Services Depository
Deposited On:02 Dec 2022 23:57
Last Modified:04 Dec 2022 21:34

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